Bone tissue material properties are altered during osteoporosis
Citation:
McNamara LM, Prendergast PJ, Schaffler MB, Bone tissue material properties are altered during osteoporosis, Journal of Musculoskeletal and Neuronal Interactions, 5, 4, 2005, 342 - 343Download Item:
Abstract:
Measurement of the effects of osteoporosis
on the mechanical behavior of bone has been performed
using whole bone testing, or testing of volumes of ovariectomized
cancellous bone1-3 and these studies revealed a
decrease in macro-level bone strength. However, it is not
clear whether these changes were due only to the reduction
in bone mass or whether a reduction in tissue strength also
contributed. A number of studies report that the mineral
content is unchanged or slightly lower in the osteoporotic
bone tissue4 or that there is an increase in the mineral content
and a lack of collagen5-7. Such microstructural changes
suggest that a corresponding change in the mechanical
behavior of the tissue should ensue during osteoporosis.
However, to date, the tissue level properties and tissue level
mineral content of osteoporotic trabecular bone have never
been measured and so such ideas remain conjecture.
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Grant Number
European Union (EU)
Author's Homepage:
http://people.tcd.ie/pprenderDescription:
PUBLISHED
Author: Prendergast, Patrick John
Publisher:
HylonomeSeries/Report no:
Journal of Musculoskeletal and Neuronal Interactions;5;
4;
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BioengineeringMetadata
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