Browsing by Author "Prendergast, Patrick John"
Now showing items 1-18 of 18
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Biochemical Markers of the Mechanical Quality of Engineered Hyaline Cartilage
(Springer, 2007)The aim of this study was to determine whether or not biochemical markers can be used as surrogate measures for the mechanical quality of tissue engineered cartilage. The biochemical composition of tissue engineered ... -
Biomechanics of ossiculoplasty
(Rila, 2003)Many different designs of prostheses are available for middle ear surgery. Clinical comparisons of such prostheses are often difficult because of the large number of variables involved in the clinical outcome; including ... -
Bone tissue material properties are altered during osteoporosis
(Hylonome, 2005)Measurement of the effects of osteoporosis on the mechanical behavior of bone has been performed using whole bone testing, or testing of volumes of ovariectomized cancellous bone1-3 and these studies revealed a decrease ... -
Developing bones are differentially affected by compromised skeletal muscle formation
(2010)Mechanical forces are essential for normal adult bone function and repair, but the impact of prenatal muscle contractions on bone development remains to be explored in depth in mammalian model systems. In this study, we ... -
Effect of a degraded core on the mechanical behaviour of tissue-engineered cartilage constructs: a poro-elastic finite element analysis
(Springer, 2004)The structure and functionality of tissue-engineered cartilage is determined by the tissue culture conditions and mechanical conditioning during growth. The quality of tissue-engineered cartilage can be evaluated using ... -
The effect of pore size on permeability and cell attachment in collagen scaffolds for tissue engineering.
(IOS Press, 2007)The permeability of scaffolds and other three-dimensional constructs used for tissue engineering applications is important as it controls the diffusion of nutrients in and waste out of the scaffold as well as influencing ... -
The effect of prosthesis design on vibration of the reconstructed ossicular chain: a comparative finite element analysis of four prostheses
(Wolters Kluwer, 2003)Hypothesis: We hypothesize that the differences in the bioacoustic performance of ossicular replacement prosthesis designs, and insertion positions, can be quantified using finite element analysis. Background: Many ... -
In silico prediction of the mechanobiological response of arterial tissue: application to angioplasty and stenting
(2011)One way to restore physiological blood flow to occluded arteries involves the deformation of plaque using an intravascular balloon and preventing elastic recoil using a stent. Angioplasty and stent implantation cause ... -
The influence of ventilation tube design on the magnitude of stress imposed at the implant/tympanic membrane interface
(Elsevier, 2008)The design of ventilation tubes or grommets is thought to have a considerable influence on their performance. A computational model (finite element method) was used to investigate the significance of four design parameters ... -
Loss of trabeculae by mechano-biological means may explain rapid bone loss in osteoporosis.
(2008)Osteoporosis is characterized by rapid and irreversible loss of trabecular bone tissue leading to increased bone fragility. In this study, we hypothesize two causes for rapid loss of bone trabeculae; firstly, the perforation ... -
Mechanics applied to skeletal ontogeny and phylogeny
(Springer, 2002)The musculo-skeletal system serves the mechanical function of creating motion and transmitting loads. It is made up mainly of four components: bone, cartilage, muscle and fibrous connective tissue. These have evolved over ... -
Mechano-regulation of stem cell differentiation and tissue regeneration in osteochondral defects
(Elsevier, 2005)Cartilage defects that penetrate the subchondral bone can undergo spontaneous repair through the formation of a fibrous or cartilaginous tissue mediated primarily by mesenchymal stem cells from the bone marrow. This ... -
Modelling damage growth and failure in elastic materials with random defect distributions
(Royal Irish Academy, 2004)Failure in materials under cyclic loading occurs by the growth and propagation of cracks. If they are sufficiently numerous, the cracks can be considered to be continuously distributed in the material. In this paper, a ... -
Papers in Biomechanics and Bioengineering
(Trinity College (Dublin, Ireland)., 2009)This is the account of the papers submitted for the degree of Doctor in Science. The papers address the following topics in biomechanics and bioengineering. Mechanobiology and tissue engineering, Implant design and testing ... -
Prediction of optimal mechanical properties for a scaffold used in osteochondral defect repair
(Mary Ann Liebert, 2006)The optimal mechanical properties of a scaffold to promote cartilage generation in osteochondral defects in vivo are not known. During normal daily activities cartilage is subjected to large cyclic loads that not only ... -
Tissue differentiation and bone regeneration in an osteotomized mandible: a computational analysis of the latency period
(Springer, 2008)Mandibular symphyseal distraction osteogenesis is a common clinical procedure to modify the geometrical shape of the mandible for correcting problems of dental overcrowding and arch shrinkage. In spite of consolidated ...
