dc.contributor.author | GILL, MICHAEL | |
dc.contributor.author | SEGURADO, RICARDO | |
dc.date.accessioned | 2009-11-26T16:39:09Z | |
dc.date.available | 2009-11-26T16:39:09Z | |
dc.date.issued | 2005 | |
dc.date.submitted | 2005 | en |
dc.identifier.citation | Segurado, Ricardo and Conroy, Judith and Meally, Eleanor and Fitzgerald, Michael and Gill, Michael and Gallagher, Louise `Confirmation of association between autism and the mitochondrial aspartate/glutamate carrier SLC25A12 gene on chromosome 2q31? in American Journal of Psychiatry, 162, (11), 2005, pp 2182 - 2184 | en |
dc.identifier.other | Y | en |
dc.identifier.other | Y | |
dc.identifier.uri | http://hdl.handle.net/2262/34993 | |
dc.description | PUBLISHED | en |
dc.description.abstract | OBJECTIVE: Autism is a neurodevelopmental disorder with childhood onset and a known major genetic component. A recent study identified a highly significant association between autism and a two-single-nucleotide-polymorphism haplotype in the SLC25A12 gene, with a homozygote genotype relative risk between 2.4 and 4.8. The authors? goal was to investigate this association with autism in Irish affected child-parent trios because replication in an independent sample is essential in the validation of such potentially important findings. METHOD: Markers rs2056202 and rs2292813 were genotyped in a total of 158 trios (442 individuals). The Transmission Disequilibrium Test was used to examine these markers for association with autism. RESULTS: In agreement with the recent study, the authors found significant association between autism and the C alleles of both rs2056202 and rs2292813 as well as the two-marker haplotype. CONCLUSIONS: These findings provide replication of the association between autism and SLC25A12. | en |
dc.format.extent | 85033 bytes | |
dc.format.extent | 2182 | en |
dc.format.extent | 2184 | en |
dc.format.mimetype | application/pdf | |
dc.language.iso | en | en |
dc.publisher | American Psychiatric Association | en |
dc.relation.ispartofseries | American Journal of Psychiatry | en |
dc.relation.ispartofseries | 162 | en |
dc.relation.ispartofseries | 11 | en |
dc.rights | Y | en |
dc.subject | Psychiatry | en |
dc.title | Confirmation of association between autism and the mitochondrial aspartate/glutamate carrier SLC25A12 gene on chromosome 2q31 | en |
dc.type | Journal Article | en |
dc.contributor.sponsor | Health Research Board | |
dc.type.supercollection | scholarly_publications | en |
dc.type.supercollection | refereed_publications | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/rsegurdo | |
dc.identifier.rssinternalid | 13247 | |
dc.identifier.rssuri | http://dx.doi.org/10.1176/appi.ajp.162.11.2182 | |