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dc.contributor.authorJOHNSON, KATHERINEen
dc.contributor.authorROBERTSON, IANen
dc.contributor.authorHAWI, ZIARIHen
dc.contributor.authorGILL, MICHAELen
dc.contributor.authorFITZGERALD, MICHAELen
dc.date.accessioned2009-11-26T16:37:49Z
dc.date.available2009-11-26T16:37:49Z
dc.date.issued2007en
dc.date.submitted2007en
dc.identifier.citationBellgrove MA, Barry E, Johnson KA, Cox M, Dáibhis A, Daly M, Hawi Z, Lambert D, Fitzgerald M, McNicholas F, Robertson IH, Gill M, Kirley A., Spatial attentional bias as a marker of genetic risk, symptom severity and stimulant response in ADHD., Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 33, 10, 2007, 2536 - 2545en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/34991
dc.descriptionPUBLISHEDen
dc.description(213) Attention-deficit hyperactivity disorder (ADHD) is a heritable childhood onset disorder that is marked by variability at multiple levels including clinical presentation, cognitive profile, and response to stimulant medications. It has been suggested that this variability may reflect etiological differences, particularly, at the level of underlying genetics. This study examined whether an attentional phenotype-spatial attentional bias could serve as a marker of symptom severity, genetic risk, and stimulant response in ADHD. A total of 96 children and adolescents with ADHD were assessed on the Landmark Task, which is a sensitive measure of spatial attentional bias. All children were genotyped for polymorphisms (3' untranslated (UTR) and intron 8 variable number of tandem repeats (VNTRs)) of the dopamine transporter gene (DAT1). Spatial attentional bias correlated with ADHD symptom levels and varied according to DAT1 genotype. Children who were homozygous for the 10-repeat allele of the DAT1 3'-UTR VNTR displayed a rightward attentional bias and had higher symptom levels compared to those with the low-risk genotype. A total of 26 of these children who were medication naive performed the Landmark Task at baseline and then again after 6 weeks of stimulant medication. Left-sided inattention (rightward bias) at baseline was associated with an enhanced response to stimulants at 6 weeks. Moreover, changes in spatial bias with stimulant medications, varied as a function of DAT1 genotype. This study suggests an attentional phenotype that relates to symptom severity and genetic risk for ADHD, and may have utility in predicting stimulant response in ADHD.en
dc.description.abstractAttention-deficit hyperactivity disorder (ADHD) is a heritable childhood onset disorder that is marked by variability at multiple levels including clinical presentation, cognitive profile, and response to stimulant medications. It has been suggested that this variability may reflect etiological differences, particularly, at the level of underlying genetics. This study examined whether an attentional phenotype-spatial attentional bias could serve as a marker of symptom severity, genetic risk, and stimulant response in ADHD. A total of 96 children and adolescents with ADHD were assessed on the Landmark Task, which is a sensitive measure of spatial attentional bias. All children were genotyped for polymorphisms (3' untranslated (UTR) and intron 8 variable number of tandem repeats (VNTRs)) of the dopamine transporter gene (DAT1). Spatial attentional bias correlated with ADHD symptom levels and varied according to DAT1 genotype. Children who were homozygous for the 10-repeat allele of the DAT1 3'-UTR VNTR displayed a rightward attentional bias and had higher symptom levels compared to those with the low-risk genotype. A total of 26 of these children who were medication naive performed the Landmark Task at baseline and then again after 6 weeks of stimulant medication. Left-sided inattention (rightward bias) at baseline was associated with an enhanced response to stimulants at 6 weeks. Moreover, changes in spatial bias with stimulant medications, varied as a function of DAT1 genotype. This study suggests an attentional phenotype that relates to symptom severity and genetic risk for ADHD, and may have utility in predicting stimulant response in ADHD.en
dc.description.sponsorshipThis work was supported by grants from the Irish Health Research Board, Science Foundation Ireland, the Irish Higher Education Authority's Programme for Research in Third-Level Institutions. MAB is supported by an Australian National Health and Medical Research Council Howard Florey Centenary Fellowship. KAJ is supported by the Health Research Board of Ireland.en
dc.format.extent2536en
dc.format.extent2545en
dc.format.mimetypeapplication/pdf
dc.language.isoenen
dc.relation.ispartofseriesNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacologyen
dc.relation.ispartofseries33en
dc.relation.ispartofseries10en
dc.rightsYen
dc.subjectADHD, attention, dopamine, genetics, stimulants, DAT1en
dc.titleSpatial attentional bias as a marker of genetic risk, symptom severity and stimulant response in ADHD.en
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/johnsokaen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/irobertsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/zhhawien
dc.identifier.peoplefinderurlhttp://people.tcd.ie/mifitzgeen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/mgillen
dc.identifier.rssinternalid48091en
dc.identifier.doihttp://dx.doi.org/10.1038/sj.npp.1301637en
dc.subject.TCDThemeNeuroscienceen
dc.subject.TCDTagADD/ADHDen
dc.subject.TCDTagADD/ADHDen
dc.subject.TCDTagADHDen
dc.subject.TCDTagADHDen
dc.subject.TCDTagATTENTION DEFICIT HYPERACTIVITY DISORDER (ADHD)en
dc.subject.TCDTagAdolescent Psychiatryen
dc.subject.TCDTagAttention Deficit Hyperactivity Disorder (ADHD)en
dc.subject.TCDTagCHILD PSYCHIATRYen
dc.subject.TCDTagDISORDER ADHDen
dc.subject.TCDTagGENETIC RISKen
dc.subject.TCDTagGENETIC RISK FACTORen
dc.subject.TCDTagGENETIC RISK FACTORSen
dc.subject.TCDTagNeuropsychiatryen
dc.subject.TCDTagNeuropsychiatryen
dc.subject.TCDTagPSYCHIATRYen
dc.subject.TCDTagPsychiatryen
dc.subject.TCDTagPsychiatryen
dc.subject.TCDTagchild and adolescent Psychiatryen
dc.subject.TCDTagneurodevelopmental psychiatryen
dc.subject.TCDTagspatial attentional biasen
dc.identifier.rssurihttp://professormichaelfitzgerald.eu/en
dc.identifier.rssurihttp://www.ncbi.nlm.nih.gov/pubmed/18046306en


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