Chemistry: Recent submissions
Now showing items 6-25 of 1270
-
Development of a solution-based process for hydroxyapatite and functionalised hydroxyapatite
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2024)Hydroxyapatite coatings have long been established as a means of improving the osteointegration of metallic orthopaedic implants. Nonetheless there are both technical and commercial drawbacks associated with industrial ... -
Development of Stimuli-responsive Materials for Direct Laser Writing for the Realisation of Microactuators
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2024)Two-photon polymerisation (2PP) is a laser-based fabrication technology which can be used to fabricate complex 3D microstructures with feature sizes ~100 nm. This thesis assesses the state of the art in 2PP and presents ... -
Enantioselective effect of cysteine functionalized mesoporous silica nanoparticles in U87 MG and GM08680 human cells and Staphylococcus aureus bacteria
(2021)Chirality is a fundamental phenomenon in biological systems, since most of the biomolecules and biological components and species are chiral and therefore recognize and respond differently depending on the enantiomer ... -
On-Surface Synthesis of Polyphenylene Wires Comprising Rigid Aliphatic Bicyclo[1.1.1]Pentane Isolator Units
(2023)Bicyclo[1.1.1]pentane (BCP) motifs are of growing importance to the pharmaceutical industry as sp3 -rich bioisosteres of benzene rings and as molecular building blocks in materials science. Herein we explore the behavior ... -
A Heterometallic Porphyrin Dimer as a Potential Quantum Gate: Magneto-Structural Correlations and Spin Coherence Properties
(2023)In the development of two-qubit quantum gates, precise control over the intramolecular spin-spin interaction between molecular spin units plays a pivotal role. A weak but measurable exchange coupling is especially important ... -
Supramolecular Chirogenesis in a Sterically Hindered Porphyrin: A Critical Theoretical Analysis
(2023)Invited for the cover of this issue are the groups of Irina Osadchuk at Tallinn University of Technology and Mathias Senge at Trinity College Dublin. The image depicts how a porphyrin with two guest molecules (R)-camphor ... -
Structure of (R,R)-4-bromo-2-{4-[4-bromo-1-(4-toluenesulfonyl)-1H-pyrrol-2-yl]-1,3-dinitrobutan-2-yl}-1-(4-toluenesulfonyl)-1H-pyrrole, another ostensible by-product in the synthesis of geminal-dimethyl hydrodipyrrins
(2023)The crystal structure of (R,R)-4-bromo-2-{4-[4-bromo-1-(4-toluenesulfonyl)-1H-pyrrol-2-yl]-1,3-dinitrobutan-2-yl}-1-(4-toluenesulfonyl)-1H-pyrrole (1, C26H24Br2N4O8S2) is presented. The title compound was isolated ... -
Strapped Porphyrins as Model Systems for Atropisomeric Photosensitizer Drugs
(2023)The time dependence of atropisomer interconversion has limited the pursuit of single atropisomer drug candidates, even in circumstances where one atropisomer presents favorable biological activity over another. Moderate ... -
The Photosensitizer Temoporfin (mTHPC) - Chemical, Pre-clinical and Clinical Developments in the Last Decade
(2023)This review follows the research, development and clinical applications of the photosensitizer 5,10,15,20-tetra(m-hydroxyphenyl)chlorin (mTHPC, temoporfin) in photodynamic (cancer) therapy (PDT) and other medical applications. ... -
Structures of S-(pyridin-2-yl) 4-nitrobenzothioate, S-(pyridin-2-yl) 4-methylbenzothioate and S-(pyridin-2-yl) 4-methoxybenzothioate: building blocks for low-symmetry multifunctional tetrapyrroles
(2023)The crystal structures of three S-(pyridin-2-yl) benzothioesters with varying para-phenyl substituents are presented, namely, S-(pyridin-2-yl) 4-nitrobenzo-thioate (1, C12H8N2O3S), S-(pyridin-2-yl) 4-methylbenzothioate (2, ... -
The role of aromaticity in the cyclization and polymerization of alkyne-substituted porphyrins on Au(111)
(2023)Aromaticity is an established and widely used concept for the prediction of the reactivity of organic molecules. However, its role remains largely unexplored in on-surface chemistry, where the interaction with the substrate ... -
Fabrication of Nanoporous Membrane-like Thin Layers via Block Copolymer Lithography of P2VP-b-PS Inverse Systems and their Potential Applications
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2024)The large-scale fabrication of nanoporous materials and substrates has generated significant research interest on account of the wide range of possible applications, including nanophotonics, optoelectronics, biomedical ... -
Spectroscopic and Crystallographic Evaluation of Ruthenium(II) Complexes Bearing Phenanthroline-Naphthalimide Ligands
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2023)Spectroscopic and Crystallographic Evaluation of Ruthenium(II) Complexes Bearing Phenanthroline-Naphthalimide Ligands Deirdre Ann McAdams This Thesis predominantly focusses on the design, synthesis, and characterisation ... -
Current Chemistry Investigators (CCI): Development and Evaluation of a Scientist in a Classroom Electrochemistry Workshop
(2023)Over the course of the COVID-19 pandemic, school students suffered from a reduction in opportunities to connect with higher education institutions, meet scientific role models in person, discuss scientific career options, ... -
Thiol-Ene "Click" A Radical Tool for Chemoselective Modification and Labelling of Biomolecules
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2023)Thiol-Ene Click chemistry represents a venerable reaction in chemical synthesis, allowing the efficient formation of a sulfur-carbon bond from thiol and alkene reaction partners. This reaction has found myriad applications ... -
The Advanced Electron Microscopy Characterisation of Oxide Materials at the Atomic Level for Energy Storage and Conversion Technologies
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2023)At the forefront of the challenges faced by modern-day society is the growing demand for clean and renewable energy sources. This challenge has been met by a surge in research activities on the development of electrochemical ... -
Fluorescent probes to target nucleic acids
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2023)Guanine-quadruplexes (G-quadruplexes) are non-canonical nucleic acid structures that consist of two or more stacked G-tetrads further stabilized by monovalent-cations. These structures are stable under physiological ... -
Organocatalysis by halogen bonding donors: A promising complement to hydrogen bond-based catalysis.
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2023)Catalytic transformations, previously dominated by metal catalysts, have seen exponential growth in the use of organocatalysts over the last two decades. The emergence of small organic molecules employed to facilitate ... -
Solvent-Engineered Tin(II) Oxide for Applications in Energy Storage Devices
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2023)With the global economy finally accepting of the harm caused by fossil fuels to the planet as a whole and the reality that they are a finite resource, ambitious plans are being made to transition to carbon-neutral economies ... -
Scanning Tunneling Microscopy Visualisation of Emergent Grain Boundaries on Cu (111) Surfaces
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2023)While nanocrystalline materials offer numerous advantages in various applications due to their superior properties, the presence of grain boundaries inherent to these materials can have a detrimental impact on their ...