Browsing Chemistry by Subject "Ubiquitin"
Now showing items 1-3 of 3
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Molecular basis of USP7 inhibition by selective small-molecule inhibitors.
(2017)Ubiquitination controls the stability of most cellular proteins, and its deregulation contributes to human diseases including cancer. Deubiquitinases remove ubiquitin from proteins, and their inhibition can induce the ... -
Novel Approaches to Probe the Activity of Deubiquitinating Enzymes
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2021)Ubiquitination is a highly conserved post-translational modification that regulates a multitude of critical cellular events. This process is orchestrated by a complex enzymatic network. Deubiquitinating enzymes (DUBs) ... -
Strategies to Target Specific Components of the Ubiquitin Conjugation/Deconjugation Machinery
(2020)The regulation of ubiquitination status in the cell is controlled by ubiquitin ligases acting in tandem with deubiquitinating enzymes. Ubiquitination controls many key processes in the cell from division to death making ...