Browsing Chemistry by Subject "Genetics"
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Substituted dipyridophenazine complexes of Cr(III): synthesis, enantiomeric resolution and binding interactions with calf thymus DNA.
(2010)[Cr(phen)2(X2dppz)]3+ {X = H, Me, or F} have been synthesised, characterised, and chromatographically resolved into their constituent ? and ? enantiomers. The DNA-binding interactions of each of the racemic complexes were ... -
Towards more specific O6-Methylguanine-DNA methyltransferase (MGMT) inactivators
(2011)Searching for a novel family of inactivators of the human DNA repair protein O6?methylguanine?DNA methyltransferase (MGMT) which is known to bind to the DNA minor groove, we have computationally modelled and synthesised ... -
Understanding the DNA binding of novel non-symmetrical guanidinium/2-aminoimidazolinium derivatives.
(2010)Biophysical studies have been carried out on a family of asymmetric guanidinium-based diaromatic derivatives to assess their potential as DNA minor groove binding agents. To experimentally assess the binding of these ...