Browsing Chemistry by Subject "Cancer"
Now showing items 1-17 of 17
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Enantioselective effect of cysteine functionalized mesoporous silica nanoparticles in U87 MG and GM08680 human cells and Staphylococcus aureus bacteria
(2021)Chirality is a fundamental phenomenon in biological systems, since most of the biomolecules and biological components and species are chiral and therefore recognize and respond differently depending on the enantiomer ... -
Getting it right: 3D cell cultures for the assessment of photosensitizers for photodynamic therapy
(2015)Core quote “Cancer drug screening is rapidly moving towards the use of 3D cell models. The added complexity of PDT action makes this a conditio sine qua non for the screening of new photosensitizers.” -
Ligand-Targeted Delivery of Photosensitizers for Cancer Treatment
(2020)Photodynamic therapy (PDT) is a promising cancer treatment which involves a photosensitizer (PS), light at a specific wavelength for PS activation and oxygen, which combine to elicit cell death. While the illumination ... -
Platelets, photosensitizers and PDT
(2013)Photodynamic therapy (PDT) has both direct cell and indirect vascular effects. Both are well established and the latter has given rise to specifically target angiogenesis in PDT treatments. While the vascular effects are ... -
Simple but powerful: Phenanthroline-based small molecules for cellular imaging and cancer screening
(2011)A two-step synthetic procedure gives highly fluorescent phenanthroline molecular probes. The compounds localize in the endoplasmic reticulum and their potential as bioactive probes was evaluated. The materials are quickly ... -
Specific Drug Formulation Additives: Revealing the Impact of Architecture and Block Length Ratio
(2015)Combining poly(ethylene glycol) (PEG) with sequence-defined peptides in PEG-peptide conjugates offers opportunities to realize next-generation drug formulation additives for overcoming undesired pharmacological profiles ... -
Strategies to Target Specific Components of the Ubiquitin Conjugation/Deconjugation Machinery
(2020)The regulation of ubiquitination status in the cell is controlled by ubiquitin ligases acting in tandem with deubiquitinating enzymes. Ubiquitination controls many key processes in the cell from division to death making ... -
Synthesis and biological evaluation of a library of glycoporphyrin compounds.
(2012)A library of glycosylated porphyrins (Glycoporphyrins) was prepared and evaluated for their PDT activity against oesophageal squamous cell carcinoma cell line OE21 in vitro. Synthetic methodology was developed to ...