Browsing Immunology by Date of Publication
Now showing items 21-40 of 51
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Human Vδ2+ γδ T cells differentially induce maturation, cytokine production, and alloreactive T cell stimulation by dendritic cells and B cells
(2014)Human γδ T cells expressing the Vγ9Vδ2 T cell receptor can induce maturation of dendritic cells (DC) into antigen-presenting cells (APC) and B cells into antibody-secreting plasma cells. Since B cells are capable of ... -
The impact of centrally and systemically administered TNFa on CNS inflamation and function
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015)Inflammation has long been recognised as a driver of dementia. However, the pathways by which inflammation alters neuronal function and causes neuronal death remain under investigation. Microglia are primed by chronic ... -
Human Vγ9Vδ2 T cells: Innate adaptors of the immune system
(2015)Unconventional T cells are gaining center stage as important effector and regulatory cells that orchestrate innate and adaptive immune responses. Human Vc9/Vd2 T cells are amongst the best understood unconventional T ... -
In vivo and ex vivo examination of the safety of oats in coeliac disease
(Trinity College (Dublin, Ireland). Department of Immunology, 2015)Coeliac disease is a chronic autoimmune disorder of the small intestine characterised by infiltration of intraepithelial lymphocytes, crypt hyperplasia and villous atrophy. It develops in genetically susceptible individuals ... -
Functional studies on human γδ T cells and their interactions with dendritic cells and B cells
(Trinity College (Dublin, Ireland). Department of Immunology, 2016)γδ T cells are innate T cells that play central roles in protection against microorganisms and cellular stress. There are three main subsets in humans: Vδ1, Vδ2 and Vδ3 T cells. The most abundant of these, Vδ2 T cells, ... -
Epigenetic targeting of CD1d increases cytolytic activity of invariant natural killer T cells against non-small cell lung cancer cells
(Trinity College (Dublin, Ireland). Department of Immunology, 2016)Lung cancer is the most common form of cancer-related death in the world, accounting for approximately 19.4% of all cancer mortalities. Currently platinum-based therapies are the gold-standard of care for non-small cell ... -
Altered endotoxin responsiveness in healthy children with Down syndrome.
(2018)Background: Down syndrome (DS) is the most common syndromic immunodeficiency with an increased risk of infection, mortality from sepsis, and autoinflammation. Innate immune function is altered in DS and therefore we examined ... -
The role of nutrition as a determinant of clinical, immunological and pharmacological outcome in HIV-infected children in Uganda
(Trinity College Dublin. School of Medicine. Discipline of Immunology, 2019)Introduction: Perinatally acquired HIV infection and malnutrition remain major public health challenges for sub-Saharan Africa health systems. HIV and malnutrition result in 50% mortality. The introduction of antiretroviral ... -
Effect of nutritional status and nutritional supplementation on clinical, nutritional and immunological outcomes among HIV infected adults in Uganda
(Trinity College Dublin. School of Medicine. Discipline of Immunology, 2019) -
The role and treatment potential of natural killer T (NKT) cells in patients with upper gastrointestinal cancers
(Trinity College Dublin. School of Medicine. Discipline of Immunology, 2019)Oesophageal adenocarcinoma (OAC), squamous cell carcinoma (SSC) and gastric cancers (GAC), collectively cause over 1.3 million deaths worldwide reported in 2018. Current therapeutic regimens focus on chemo-radiotherapy ... -
The role of innate lymphocyte metabolism in sepsis
(Trinity College Dublin. School of Medicine. Discipline of Immunology, 2020)Sepsis is the result of a dysregulated systemic immune response to microbial infection that leads to organ failure and death in about 30% of affected individuals. The antimicrobial response is biphasic with an overwhelming ... -
Immune Dysregulation in Children With Down Syndrome
(2020)Down syndrome (DS) is the most common genetic syndrome associated with immune defects. The extent of immune dysregulation in DS is substantial, spanning the innate and adaptive systems and including anomalies in: T and ... -
Improvement in cognitive impairment following a 12-week aerobic exercise intervention in individuals with non-cirrhotic chronic hepatitis C
(2020)Cognitive impairment occurs in 30%-50% of patients with non-cirrhotic chronic hepatitis C virus (HCV) infection. Exercise is beneficial in preventing and treating cognitive impairment and cardiometabolic abnormalities in ... -
Selective effects of radiotherapy on viability and function of invariant natural killer T cells in vitro
(2020)Background and purpose: Immunotherapies involving the adoptive transfer of ex vivo expanded autologous invariant natural killer (iNKT) cells are a potential option for cancer patients and are under investigation in clinical ... -
CD1d expression and invariant natural killer T-cell numbers are reduced in patients with upper gastrointestinal cancers and are further impaired by commonly used chemotherapies
(2020)Esophageal and gastric cancers collectively cause over 1.1 million deaths annually and only 20-30% of patients respond favorably to current therapies. Cellular therapies using invariant natural killer T (iNKT) cells are ... -
Increased systemic inflammation in children with Down syndrome
(2020)Children with Down syndrome (DS) develop more infections, have an increased mortality from sepsis and an increased incidence of chronic inflammatory conditions. Cytokine dysregulation may underpin these clinical sequelae ... -
Understanding the Role of IL-36 Family Cytokines in Paediatric IBD
(Trinity College Dublin. School of Medicine. Discipline of Immunology, 2021)Despite significant therapeutic advances, the global incidence of Inflammatory Bowel Diseases (IBD) continues to rise, with approximately 25% of these cases reported in childhood and adolescence. Aberrant CD4+ TΗ cell ... -
Altered distributions and functions of natural killer T cells and γδ T cells in neonates with neonatal encephalopathy, in school-age children at follow-up, and in children with cerebral palsy
(2021)We enumerated conventional and innate lymphocyte populations in neonates with neonatal encephalopathy (NE), school-age children post-NE, children with cerebral palsy and age-matched controls. Using flow cytometry, we ...