Browsing Pharmacy and Pharmaceutical Sciences (Scholarly Publications) by Author "O'Connell, Peter"
Now showing items 1-8 of 8
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The acoustic features of inhalation can be used to quantify aerosol delivery from a Diskus? dry powder inhaler
Healy, Anne-Marie; Reilly, Richard; O'Connell, Peter (2014)Some patients are unable to generate the peak inspiratory flow rate (PIFR) necessary to de-agglomerate drug particles from dry powder inhalers (DPIs). In this study we tested the hypothesis that the acoustic parameters of ... -
Cocrystal habit engineering to improve drug dissolution and alter derived powder properties
Healy, Anne-Marie; O'Connell, Peter (2016)Objectives: Cocrystallization of sulfadimidine (SDM) with suitable coformers, such as 4-aminosalicylic acid (4-ASA), combined with changes in the crystal habit can favourably alter its physicochemical properties. The aim ... -
Engineering of pharmaceutical cocrystals in an excipient matrix: Spray drying versus hot melt extrusion.
Healy, Anne-Marie; O'Connell, Peter (2018)The comparison of spray drying versus hot melt extrusion (HME) in order to formulate amorphous solid dispersions has been widely studied. However, to the best of our knowledge, the use of both techniques to form cocrystals ... -
Impact of substrate properties on the formation of spherulitic films: a case study of salbutamol sulfate
Healy, Anne-Marie; Tajber, Lidia; O'Connell, Peter (2016)Spherulitic assemblies have applications as carriers for drug delivery and as targeting vectors. Presently, the driving force behind the formation of spherulites comprising small drug molecules is not fully understood. ... -
Mitigating unwanted amorphisation: A screening method for the selection of suitable excipients
Healy, Anne-Marie; O'Connell, Peter (2016)Co-processing an active pharmaceutical ingredient (API) with a low Tg excipient has been previously reported to be an effective strategy for preventing drug amorphisation on milling. This technique relies on the ability ... -
Modelling and understanding powder flow properties and compactability of selected active pharmaceutical ingredients, excipients and physical mixtures from critical material properties
Healy, Anne-Marie; Worku, Zelalem; O'Connell, Peter (2017)The development of solid dosage forms and manufacturing processes are governed by complex physical properties of the powder and the type of pharmaceutical unit operation the manufacturing processes employs. Suitable powder ... -
Optimising the in vitro and in vivo performance of oral cocrystal formulations via spray coating
Healy, Anne-Marie; O'Connell, Peter (2018)Engineering of pharmaceutical cocrystals is an advantageous alternative to salt formation for improving the aqueous solubility of hydrophobic drugs. Although, spray drying is a well-established scale-up technique in the ... -
Polymorphism in sulfadimidine/4-aminosalicylic acid cocrystals: solid state characterization and physicochemical properties
Healy, Anne-Marie; O'Connell, Peter (2015)