Browsing Pharmacy and Pharmaceutical Sciences (Scholarly Publications) by Author "Harkin, Andrew"
Now showing items 1-6 of 6
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A role for serotonin in the antidepressant activity of NG Nitro-L-arginine in the rat forced swimming test
Harkin, Andrew (2009)The present study determined regional serotonin (5-HT) synthesis and metabolism changes associated with the nitric oxide synthase (NOS) inhibitor NG-nitro-L-arginine (L-NA) and the influence of 5-HT receptor blockade in ... -
Stress-Related Immune Markers in Depression: Implications for Treatment
Harkin, Andrew (2016)Major depression is a serious psychiatric disorder; however, the precise biological basis of depression still remains elusive. A large body of evidence implicates a dysregulated endocrine and inflammatory response system ... -
Stress-related regulation of the kynurenine pathway: Relevance to neuropsychiatric and degenerative disorders
Harkin, Andrew (2017)The kynurenine pathway (KP), which is activated in times of stress and infection has been implicated in the pathophysiology of neurodegenerative and psychiatric disorders. Activation of this tryptophan metabolising pathway ... -
Targeting the noradrenergic system for anti-inflammatory and neuroprotective effects: implications for Parkinson's disease.
Harkin, Andrew; O'Neill, Eoin (2018)Degeneration of the locus coeruleus noradrenergic system is thought to play a key role in the pathogenesis of Parkinson’s disease (PD), whereas pharmacological approaches to increase noradrenaline bioavailability may ...