Browsing Pharmacy and Pharmaceutical Sciences (Scholarly Publications) by Title
Now showing items 275-294 of 445
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N1-dansyl-spermine: a potent polyamine antagonist.
(2004)The potential polyamine antagonist action of N1-dansyl-spermine (a potent NMDA antagonist) was assessed in two in vivo mouse models of polyamine action. Co-administration of N1-dansyl-spermine (2?10 ?g, i.c.v.) with spermine ... -
Nanostructured systems containing babassu (Orbignya speciosa) oil as a potential alternative therapy for benign prostatic hyperplasia.
(2013)The oil of babassu tree nuts (Orbignya speciosa) is a potential alternative for treatment and prophylaxis of benign prostatic hyperplasia. Improved results can be obtained by drug vectorization to the hyperplastic tissue. ... -
Neuromedin U alters bioenergetics and expands the cancer stem cell phenotype in HER2-positive breast cancer
(2017)Neuromedin U (NmU) is a neuropeptide belonging to the neuromedin family. Recently, we reported a significant association between NmU and breast cancer, particularly correlating with increased aggressiveness, resistance to ... -
Non-Prescription Medicinal Products containing codeine: guidance for pharmacists on safe supply to patients
(Pharmaceutical Society of Ireland, 2010) -
Novel isosorbide di-ester compounds as inhibitors of acetylcholinesterase
(2008)We report herein that a variety of isosorbide di-esters, previously reported to be novel substrates for butyrylcholinesterase (BuChE, EC 3.1.1.8), are in fact inhibitors of the homologous enzyme acetylcholinesterase (AChE), ... -
A novel toxic alkaloid from poison hemlock (Conium maculatum L., Apiaceae): identification, synthesis and antinociceptive activity
(2012)2-Pentylpiperidine, named conmaculatin, a novel volatile alkaloid related to coniine was identified from the renowned toxic weed Conium maculatum L. (Apiaceae). The structure of conmaculatin was corroborated by synthesis ... -
Optimisation of spray drying process conditions for sugar nanoporous microparticles (NPMPs) intended for inhalation
(2011)The present study investigated the effect of operating parameters of a laboratory spray dryer on powder characteristics, in order to optimise the production of trehalose and raffinose powders, intended to be used as carriers ... -
Optimising the in vitro and in vivo performance of oral cocrystal formulations via spray coating
(2018)Engineering of pharmaceutical cocrystals is an advantageous alternative to salt formation for improving the aqueous solubility of hydrophobic drugs. Although, spray drying is a well-established scale-up technique in the ...