Browsing School of Biochemistry & Immunology by Title
Now showing items 560-579 of 1015
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Mechanistic studies on human liver Biliverdin-IX beta reductase
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2006)The reaction mechanism of human biliverdin-IXβ reductase (BVR-B) has been investigated using a number of approaches. The preference for NADPH over NADH has been examined using site-directed mutagenesis. The crystal structure ... -
Membrane Protein Crystallization in Lipidic Mesophases. A Mechanism Study Using X-ray Microdiffraction.
(2007)The membrane structural biologist seeks to understand how membrane proteins function at a molecular level. One of the most direct ways of accomplishing this requires knowing the structure of the protein, ideally at atomic ... -
Membrane Protein Crystallization in Lipidic Mesophases. Hosting lipid affects on the crystallization and structure of a transmembrane peptide.
(2011)Gramicidin is an apolar pentadecapeptide antibiotic consisting of alternating D-and L-amino acids. It functions, in part, by creating pores in membranes of susceptible cells rendering them leaky to monovalent cations. ... -
Membrane protein structure determination using crystallography and lipidic mesophases: recent advances and successes.
(2012)The crystal structure of the β 2 -adrenergic receptor in complex with an agonist and its cognate G protein has just recently been solved. It is now possible to explore in molecular detail the means by which this ... -
Memory Th1 Cells Are Protective in Invasive Staphylococcus aureus Infection.
(2015)Mechanisms of protective immunity to Staphylococcus aureus infection in humans remain elusive. While the importance of cellular immunity has been shown in mice, T cell responses in humans have not been characterised. Using ... -
MemProtMD: Automated Insertion of Membrane Protein Structures into Explicit Lipid Membranes
(2015)There has been exponential growth in the number of membrane protein structures determined. Nevertheless, these structures are usually resolved in the absence of their lipid environment. Coarse-grained molecular dynamics ... -
Metabolic and redox regulation of IL-17-producing γδ T cells
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2024)Interleukin-17 (IL-17) is a proinflammatory cytokine that contributes to a wide range of immune responses, including host defence, tissue repair, autoimmune inflammation, and tumour progression. γδ17 T cells (CD3+TCRδ+CD27-) ... -
Metabolic but not transcriptional regulation by PKM2 is important for Natural Killer cell responses
(2020)Natural Killer (NK) cells have an important role in immune responses to viruses and tumours. Integrating changes in signal transduction pathways and cellular metabolism is essential for effective NK cells responses. The ... -
Metabolic control analysis and mitochondrial function in the nerve terminal
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2009)Reduced activities of the mitochondrial electron transport chain complexes have been implicated in the pathogenesis of numerous neurodegenerative disorders such as Alzheimer’s disease (AD), Parkinson’s disease (PD) and ... -
Metabolic flux control of mitochondrial dynamics in cancer cells
(Trinity College Dublin. School of Engineering. Discipline of Electronic & Elect. Engineering, 2017) -
Metabolic reprograming in macrophage polarization.
(2014)Studying the metabolism of immune cells in recent years has emphasized the tight link existing between the metabolic state and the phenotype of these cells. Macrophages in particular are a good example of this phenomenon. ... -
Metabolic reprogramming during the Trypanosoma brucei life cycle
(2017)Cellular metabolic activity is a highly complex, dynamic, regulated process that is influenced by numerous factors, including extracellular environmental signals, nutrient availability and the physiological and developmental ... -
A Metabolic Roadblock in Inflammatory Macrophages
(2016)n this issue of Cell Reports, Van den Bossche et al. (2016) reveal that, once the M1 macrophage forms, the accompanying metabolic alterations in the mitochondria are irreversible, preventing differentiation into the more ... -
Metabolism of inflammation limited by AMPK and pseudo-starvation.
(2013)Metabolic changes in cells that participate in inflammation, such as activated macrophages and T-helper 17 cells, include a shift towards enhanced glucose uptake, glycolysis and increased activity of the pentose phosphate ... -
Metabolism, migration and memory in cytotoxic T cells
(2011)The transcriptional and metabolic programmes that control CD8(+) T cells are regulated by a diverse network of serine/threonine kinases. The view has been that the kinases AKT and mammalian target of rapamycin (mTOR) control ... -
Metformin inhibits the production of reactive oxygen species from NADH: Ubiquinone oxidoreductase to limit induction of interleukin-1β (IL-1β) and boosts interleukin-10 (IL-10) in lipopolysaccharide (LPS)-activated macrophages
(2015)Background: The antidiabetic drug and mitochondrial NADH:ubiquinone oxidoreductase (complex I) inhibitor metformin has anti-inflammatory activity. Results: Complex I inhibition decreases LPS-induced IL-1β and boosts IL-10. ... -
A method to predict residues conferring functional differences between related proteins: application to MAP kinase pathways
(The Protein Society, 2000)Physicochemical properties are potentially useful in predicting functional differences between aligned protein subfamilies. We present a method that considers physicochemical properties from ancestral sequences predicted ... -
The microbiota and immune-mediated diseases: Opportunities for therapeutic intervention
(2020)A multitude of diverse microorganisms, termed the microbiota, reside in the gut, respiratory tract, skin, and genital tract of humans and other animals. Recent advances in metagenomic sequencing and bioinformatics have ... -
Microrna regulation of bovine monocyte inflammatory and metabolic networks in an in Vivo infection model
(2014)Bovine mastitis is an inflammation-driven disease of the bovine mammary gland that costs the global dairy industry several billion dollars per year. Because disease susceptibility is a multifactorial complex phenotype, an ...