Browsing Clinical Medicine (Scholarly Publications) by Sponsor "Irish Research Council for Science Engineering and Technology"
Now showing items 1-3 of 3
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The C-type lectin SIGNR1 binds Schistosoma mansoni antigens in vitro, but SIGNR1-deficient mice have normal responses during schistosome infection
(American Society for Microbiology, 2009)The de novo immune response to infectious organisms arises from the innate recognition of pathogen-associated molecular patterns (PAMPs) by the host's pattern recognition receptors (PRRs). As the generation of type 2 ... -
Schistosoma mansoni secretes a chemokine binding protein with anti-inflammatory activity.
(Rockefeller University Press, 2005)The coevolution of humans and infectious agents has exerted selective pressure on the immune system to control potentially lethal infections. Correspondingly, pathogens have evolved with various strategies to modulate and ... -
Schistosoma mansoni worms induce anergy of T cells via selective up-regulation of programmed death ligand 1 on macrophages
(The Journal of Immunology, 2004)Infectious pathogens can selectively stimulate activation or suppression of T cells to facilitate their survival within humans. In this study we demonstrate that the trematode parasite Schistosoma mansoni has evolved with ...