Browsing Histopathology & Morbid Anatomy (Scholarly Publications) by Title
Now showing items 2-21 of 61
-
Adenovirus 12 E1A gene detection by polymerase chain reaction in both the normal and coeliac duodenum.
(1994)A 12 amino acid sequence from the adenovirus 12 E1B protein is homologous at the protein level with a similar 12-mer derived from the wheat protein A-gliadin. It has been suggested that exposure to Ad 12 could sensitise ... -
Application of statistical process control to qualitative molecular diagnostic assays.
(2014)Modern pathology laboratories and in particular high throughput laboratories such as clinical chemistry have developed a reliable system for statistical process control (SPC). Such a system is absent from the majority of ... -
Aspirin and P2Y<inf>12</inf> inhibition attenuate platelet-induced ovarian cancer cell invasion
(2015)Background: Platelet-cancer cell interactions play a key role in successful haematogenous metastasis. Disseminated malignancy is the leading cause of death among ovarian cancer patients. It is unknown why different ovarian ... -
B-Raf(V600E) and thrombospondin-1 promote thyroid cancer progression.
(2010)Although B-Raf(V600E) is the most common somatic mutation in papillary thyroid carcinoma (PTC), how it induces tumor aggressiveness is not fully understood. Using gene set enrichment analysis and in vitro and in vivo ... -
BRCA1/2 mutation analysis in 41 ovarian cell lines reveals only one functionally deleterious BRCA1 mutation.
(2013)Mutations in BRCA1/2 increase the risk of developing breast and ovarian cancer. Germline BRCA1/2 mutations occur in 8.6-13.7% of unselected epithelial ovarian cancers, somatic mutations are also frequent. BRCA1/2 mutated ... -
BRCA1/2 mutation analysis in 43 ovarian cell lines reveals only one functionally deleterious BRCA1 mutation
(2012)Introduction: Germline mutations in DNA repair genes BRCA1/2 increase the risk of developing breast and ovarian cancer. Germline BRCA1/2 mutations occur in 8.6-13.7% of unselected epithelial ovarian cancers, somatic mutations ... -
Carboplatin and taxol resistance develops more rapidly in functional BRCA1 compared to dysfunctional BRCA1 ovarian cancer cells
(2014)A major risk factor for ovarian cancer is germline mutations of BRCA1/2. It has been found that (80%) of cellular models with acquired platinum or taxane resistance display an inverse resistance relationship, that is ... -
Catching moving targets: Cancer stem cell hierarchies, therapy-resistance & considerations for clinical intervention
(2017)It is widely believed that targeting the tumour-initiating cancer stem cell (CSC) component of malignancy has great therapeutic potential, particularly in therapy-resistant disease. However, despite concerted efforts, ... -
A cloud computing database for data extraction in a Cochrane review
(2013)Background: An online database was needed for the Cochrane review ?Taxanes for the treatment of platinum pre-treated epithelial ovarian cancer? for several reasons. Firstly, a large amount of clinical parameters were to ... -
Control of reproductive floral organ identity specification in Arabidopsis by the C function regulator AGAMOUS.
(2013)The floral organ identity factor AGAMOUS (AG) is a key regulator of Arabidopsis thaliana flower development, where it is involved in the formation of the reproductive floral organs as well as in the control of meristem ... -
Correlation of p16(INK4A) expression and HPV copy number with cellular FTIR spectroscopic signatures of cervical cancer cells.
(2011)Cervical cancer, a potentially preventable disease, has its main aetiology in infection by high risk human papillomavirus (HR-HPV). Approaches to improving cervical cancer screening and diagnostic methodologies include ... -
Detection of a Tyrosine Phosphatase LAR on Intestinal Epithelial Cells and Intraepithelial Lymphocytes in the Human Duodenum.
(Hindawi, 2005)Studies of tyrosine phosphorylation in the human duodenum have indicated that proliferating cells in the middle portion of the duodenal crypt were devoid of this feature, suggesting that tyrosine kinase activation is not ... -
Developing ovarian cancer stem cell models: laying the pipeline from discovery to clinical intervention.
(2014)Despite decades of research, ovarian cancer is still associated with unacceptably high mortality rates, which must be addressed by novel therapeutic approaches. One avenue through which this may be achieved is targeting ... -
THE EMT-ACTIVATOR ZEB1 IS UNRELATED TO PLATINUM DRUG RESISTANCE IN OVARIAN CANCER BUT PREDICTIVE OF SURVIVAL
(2014)Background: Ovarian cancer is treated by surgery followed by platinum/taxane combination chemotherapy. Initial response rates are high, but up to 80% of ovarian cancer patients will eventually relapse with drug-resistant ... -
Endosomal gene expression: a new indicator for prostate cancer patient prognosis?
(2015)Prostate cancer continues to be a major cause of morbidity and mortality in men, but a method for accurate prognosis in these patients is yet to be developed. The recent discovery of altered endosomal biogenesis in prostate ... -
Endothelial NOS, estrogen receptor beta, and HIFs cooperate in the activation of a prognostic transcriptional pattern in aggressive human prostate cancer.
(2009)The identification of biomarkers that distinguish between aggressive and indolent forms of prostate cancer (PCa) is crucial for diagnosis and treatment. In this study, we used cultured cells derived from prostate tissue ...