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Molecular genetic evidence for overlap between general cognitive ability and risk for schizophrenia: a report from the Cognitive Genomics consorTium (COGENT).
(2014)
It has long been recognized that generalized deficits in cognitive ability represent a core component of schizophrenia (SCZ), evident before full illness onset and independent of medication. The possibility of genetic ...
Molecular pathways involved in neuronal cell adhesion and membrane scaffolding contribute to schizophrenia and bipolar disorder susceptibility.
(2011)
Susceptibility to schizophrenia and bipolar disorder may involve a substantial, shared contribution from thousands of common genetic variants each of small effect. Identifying if risk variants map to specific molecular ...
No evidence that runs of homozygosity are associated with schizophrenia in an Irish genome-wide association dataset
(2014)
Runs of homozygosity (ROH), regions of the genome containing many consecutive homozygous SNPs, may represent two copies of a haplotype inherited from a common ancestor. A rare variant on this haplotype could thus be present ...
GWA study data mining and independent replication identify cardiomyopathy-associated 5 (CMYA5) as a risk gene for schizophrenia.
(Nature, 2010)
We conducted data-mining analyses using the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) and molecular genetics of schizophrenia genome-wide association study supported by the genetic association ...
Early Visual Processing Deficits in Dysbindin-Associated Schizophrenia
(2008)
Background:
Variation at the dysbindin gene (DTNBP1) has been associated with increased risk for schizophrenia in numerous independent samples and recently with deficits in general and domain-specific cognitive processing. ...
Genome-wide association study identifies five new schizophrenia loci.
(2011)
We examined the role of common genetic variation in schizophrenia in a genome-wide association
study of substantial size: a stage 1 discovery sample of 21,856 individuals of European ancestry
and a stage 2 replication ...
Fine mapping of ZNF804A and genomime-wide significant evidence for it's involvement in Schizophrenia and bipolar disorder.
(2011)
A recent genome-wide association study (GWAS) reported evidence for association between rs1344706 within ZNF804A (encoding zinc-finger protein 804A) and schizophrenia (P=1.61 × 10(-7)), and stronger evidence when the ...
Geonome-wide linkage analysis of 972 bipolar pedigrees using single-nucleotide polymorphisms
(2011)
Because of the high costs associated with ascertainment of families, most linkage studies of Bipolar I disorder (BPI) have used relatively small samples. Moreover, the genetic information content reported in most studies ...