Browsing Psychiatry (Scholarly Publications) by Author "FRODL, THOMAS"
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Assessing Problem based learning in Child and Adolescent Psychiatry at the Trinity College Dublin Ireland
GILL, MICHAEL; GALLAGHER, LOUISE; FRODL, THOMAS (2012) -
BDNF Val66Met genotype interacts with childhood adversity and influences the formation of hippocampal subfields.
FRODL, THOMAS; GILL, MICHAEL (2014) -
Effect of childhood maltreatment on brain structure in adult patients with major depressive disorder and healthy participants.
FAGAN, ANDREW; FRODL, THOMAS; CARBALLEDO, ANGELA; MEANEY, JAMES (2014)BACKGROUND: Childhood maltreatment has been found to play a crucial role in the development of psychiatric disorders. However, whether childhood maltreatment is associated with structural brain changes described for ... -
Effect of genetic variant in BICCI on functional and structural brain changes in depression
GILL, MICHAEL; DONOHOE, GARY; FAGAN, ANDREW; MORRIS, DEREK; FRODL, THOMAS (2012) -
The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data.
FRODL, THOMAS; DONOHOE, GARY; LOPEZ, LORNA (2014)The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a collaborative network of researchers working together on a range of large-scale studies that integrate data from 70 institutions worldwide. ... -
Further evidence of alerted default network connectivity and association with theory of mind ability in schizophrenia
GILL, MICHAEL; DONOHOE, GARY; CORVIN, AIDEN; MORRIS, DEREK; FRODL, THOMAS (2016)Background: Resting-state functional magnetic resonance imaging (rs-fMRI) has repeatedly shown evidence of altered functional connectivity of large-scale networks in schizophrenia. The relationship between these connectivity ... -
How does the brain deal with cumulative stress? A review with focus on developmental stress, HPA axis function and hippocampal structure in humans
FRODL, THOMAS; O'KEANE, VERONICA (2012)There is evidence that excessive stress exposure of the brain, mediated through the neurotoxic effects of cortisol and possibly neuroinflammation, causes damage to brain structure and function: the glucocorticoid cascade ... -
Microstructural Correlates of Resilience against Major Depressive Disorder: Epigenetic Mechanisms?
CARBALLEDO, ANGELA; FRODL, THOMAS; FAGAN, ANDREW; LISIECKA, DANUTA; MEANEY, JAMES; KELLEHER, DERMOT (2010)Mental disorders are a major cause of long-term disability and are a direct cause of mortality, with approximately 800.000 individuals dying from suicide every year worldwide ? a high proportion of them related to major ... -
Neural correlates of treatment outcome in major depression.
FRODL, THOMAS; LISIECKA, DANUTA (2011)There is a need to identify clinically useful biomarkers in major depressive disorder (MDD). In this context the functional connectivity of the orbitofrontal cortex (OFC) to other areas of the affect regulation circuit is ... -
The NOS1 variant rs6490121 is associated with variation in prefrontal function and gray matter density in healthy individuals
FRODL, THOMAS; DONOHOE, GARY (JAMES); GILL, MICHAEL; CORVIN, AIDEN PETER; NEWELL, FIONA; ROSE, EMMA; FAHEY, CIARA; GARAVAN, HUGH PATRICK; BOKDE, ARUN LAWRENCE WARREN; O'DOHERTY, JOHN PHILIP; MC GRATH, JANE; KELLY, SINEAD; ROBERTSON, IAN H; MORRIS, DEREK (Elsevier, 2012)A common polymorphism within the nitric oxide sythanse-1 (NOS1) gene (rs6490121), initially identified as risk variant for schizophrenia, has been associated with variation in working memory and IQ. Here we investigated ... -
Recruitment of the left hemispheric emotional attention neural network in risk for and protection from depression.
FRODL, THOMAS (2013)BACKGROUND: Family history of major depressive disorder (MDD) increases individuals' vulnerability to depression and alters the way depression manifests itself. Emotion processing and attention shifting are functions ... -
ZNF804A risk allele is associated with relatively intact gray matter volume in patients with schizophrenia
CORVIN, AIDEN PETER; ROSE, EMMA; DONOHOE, GARY (JAMES); FRODL, THOMAS; MORRIS, DEREK; GILL, MICHAEL (Elsevier, 2010)ZNF804A rs1344706 is the first genetic risk variant to achieve genome wide significance for psychosis. Following earlier evidence that patients carrying the ZNF804A risk allele had relatively spared memory function compared ...