Browsing Psychiatry (Theses and Dissertations) by Title
Now showing items 61-73 of 73
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The role of FKBP5 genetics and epigenetics in mediating the effects of early life adversity on emotional processing brain regions in major depressive disorder
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2018)Major depressive disorder (MDD) is the most widespread psychiatric illness and is characterized by loss of pleasure, depressed mood, sleep disturbances and anxiety. Recently, an inflammatory theory of MDD has emerged, which ... -
Social cognition in borderline personality disorder : an MRI investigation
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2013)There is increasing evidence for subtle changes in brain morphology and function in patients with borderline personality disorder (BPD). The four study arms in this thesis seek to investigate the differences in personality, ... -
Structural Changes of Brain Areas Involved in Emotion and Memory Processing across Lifespan
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2020)People are defined by their genes, familiar background and personal experiences, that can have either a negative or positive impact. Altogether, this represents and shapes their decisions, behaviours and relationships with ... -
Subsyndromal depression and anxiety predictors, consequences and two year outcome in the Irish elderly
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2008)Depression is the commonest mental illness in late life and frequently occurs co- morbidly with anxiety. While all levels of illness severity have been reported a significant proportion of older adults suffer with clinically ... -
Symptoms of autism in ADHD : a familial trait in a subset of children with ADHD which correlates with comorbid oppositional defiant disorder, conduct disorder and motor disorder
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2009)Introduction; This study examines autism symptoms in a sample of children with ADHD, in their siblings, and in a control sample. Study sample: 821 children with ADHD, combined type who were participating in the International ... -
The aging brain : an investigation into cognitive training and resting state networks in healthy older adults
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2013)Investigating the complexities surrounding the aging brain is of vital importance if we are to fully understand the mechanisms of aging. A greater understanding of aging may perhaps pave the way for new ideas and innovations ... -
The contributions of knowledge and contact to the stigma of mental illness
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2008)Study One is a single face-to-face questionnaire study of 243 patients with psoriasis and/or arthritis. Because leprosy is an infectious condition, psoriasis is a better model of a stigmatising skin disorder likely to cause ... -
The effect of catecholaminergic genes on executive functions : a behavioural and fMRI study
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2009)This thesis describes a study in two parts aimed at elucidating genetic links to executive functions and their neurological correlates. The catecholamines (in particular dopamine and noradrenaline) are known to be heavily ... -
The effects of depression and electroconvulsive therapy on retrospective memory and general cognition : a longitudinal study
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2012)The objectives of this work were to investigate the effects of depression on retrospective memory, in addition to attention, psychomotor and executive function, in depressed patients receiving pharmacotherapy treatment ... -
The impact of schizophrenia genome wide association study genes on functional connectivity : a functional magnetic resonance imaging study
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2014)Genome-wide association studies (GWAS) have identified several genetic variants associated with increased schizophrenia risk. However, the specific mechanisms by which these variants increase risk are not fully understood. ... -
The impact of schizophrenia genome-wide association study genes on neurocognition and social cognition : a behavioural study
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2013)Genome wide association studies (GWAS) have established numerous previously unidentified variants associated with increased risk for schizophrenia (SZ). Exactly how most of these variants exert their influence remains ... -
The influence of Alzheimer's dementia on time spent caregiving for persons with Down Syndrome
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2003)Background: Persons with Down syndrome (DS) are at increased risk of Alzheimer’s type dementia (AD) when compared to the general population, yet little attention has been paid to the impact of the illness on such persons ... -
The neural basis of reward processing in Autism Spectrum Disorder : brain function, structure and connectivity
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2013)Autism spectrum disorder (ASD) is a pervasive developmental disorder defined by impairments in reciprocal social interaction and communication, as well as stereotyped behaviour and repetitive interests (Lord et al., 2011). ...
