Browsing Psychiatry (Theses and Dissertations) by Date of Publication
Now showing items 21-40 of 73
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Frailty in an older population : the impact on community-dwelling elders, dementia patients and older caregivers
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2012)Frailty represents one of the greatest gerontological challenges faced by societies in coming years. Growing numbers of older citizens leads not only to increasing numbers of healthy elders, but also frail and disabled elders. -
Brain structure, function and connectivity in Autism Spectrum Disorders
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2012)In this study, two neuroimaging modalities were used to investigate neural connectivity in individuals with autism spectrum disorder; functional magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI). -
High dose right unilateral versus moderate dose bilateral ECT for major depression : time to re-orientation, physical functioning, quality of life and attitudes
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2012)The objective of this study was to compare the effects of 1.5 x seizure threshold (ST) bitemporal ECT with high dose (6 x ST) right unilateral (RUL) ECT with respect to immediate recovery from treatment, change in physical ... -
Investigation of S100B gene as a risk factor for biopolar disorder and schizophrenia
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2012)Calcium-binding protein S100B has been implicated in the pathology of bipolar affective disorder (BPAD) and schizophrenia (SZP). S100B protein levels are elevated in serum of patients with both disorders compared to controls. ... -
The effects of depression and electroconvulsive therapy on retrospective memory and general cognition : a longitudinal study
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2012)The objectives of this work were to investigate the effects of depression on retrospective memory, in addition to attention, psychomotor and executive function, in depressed patients receiving pharmacotherapy treatment ... -
Electrophysiological event-related-potentials & their association with genome-wide-associated risk variants in schizophrenia
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2012)This thesis describes the use of electrophysiological event- related-potentials as a method for understanding, at the cortical level, the functional significance of putative schizophrenia susceptibility genes identified ... -
Application of functional genomics to psychiatric disorders
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2012)Schizophrenia and bipolar disorder are common and severe psychiatric illnesses directly affecting approximately 1% of the population worldwide. Both have a devastating impact on the lives of those affected not to mention ... -
Functional neural differences in emotional regualtion between patients with MDD and healthy controls in the context of the vulnerability factors : family history of MDD, BDNF Val66Met polymorphism
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2012)Emotional regulation is a key mechanism which shows disturbances during major depressive disorder (MDD), and which may be modified by certain factors enhancing vulnerability to MDD. Two vulnerability factors were tested ... -
Fuctional and structural brain changes in ageing related to emotional processing
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2012)Of all mental abilities emotional processing is well-preserved in healthy ageing. In spite of this, the neural substrates of emotional processing in ageing are still not fully understood. In this project several experiments ... -
Investigation of rare sequence variants in putative susceptibility genes for schizophrenia and autism spectrum disorders
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2013)Schizophrenia (SZ) and Autism Spectrum Disorders (ASD) are complex neuropsychiatric disorders that have a very large health, societal and economic burden in Ireland. They affect approximately 1% and 0.8% of the population ... -
Investigating risk factors and clinical correlates of copy number variants in Autism Spectrum Disorders and schizophrenia
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2013)Autism Spectrum Disorders (ASD) (OMIM 209850) and schizophrenia (OMIM 181510) are both complex neurodevelopmental disorders with extensive emotional and physical costs. Although there has been some progress in understanding ... -
The aging brain : an investigation into cognitive training and resting state networks in healthy older adults
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2013)Investigating the complexities surrounding the aging brain is of vital importance if we are to fully understand the mechanisms of aging. A greater understanding of aging may perhaps pave the way for new ideas and innovations ... -
The neural basis of reward processing in Autism Spectrum Disorder : brain function, structure and connectivity
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2013)Autism spectrum disorder (ASD) is a pervasive developmental disorder defined by impairments in reciprocal social interaction and communication, as well as stereotyped behaviour and repetitive interests (Lord et al., 2011). ... -
Social cognition in borderline personality disorder : an MRI investigation
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2013)There is increasing evidence for subtle changes in brain morphology and function in patients with borderline personality disorder (BPD). The four study arms in this thesis seek to investigate the differences in personality, ... -
Characterisation of MACROD2, a putative autism susceptibility gene : translating Genome-Wide Analysis to causation
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2013)Genome Wide Association studies (GWAS) have been used to identify genetic markers which have strong statistical association with a disease. Establishing a functional consequence of association is required to determine a ... -
The impact of schizophrenia genome-wide association study genes on neurocognition and social cognition : a behavioural study
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2013)Genome wide association studies (GWAS) have established numerous previously unidentified variants associated with increased risk for schizophrenia (SZ). Exactly how most of these variants exert their influence remains ... -
The impact of schizophrenia genome wide association study genes on functional connectivity : a functional magnetic resonance imaging study
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2014)Genome-wide association studies (GWAS) have identified several genetic variants associated with increased schizophrenia risk. However, the specific mechanisms by which these variants increase risk are not fully understood. ... -
Investigating the effects of schizophrenia genome-wide associated variants on white matter microstructure and brain morphology using diffusion tenson imaging and quantitative MRI
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2014)This thesis describes four studies that aim to to elucidate the effects of schizophrenia genome-wide associated variants on measures of white matter microstructure, cortical thickness, surface area and subcortical volume. ... -
Genetic and molecular studies of rare variation in schizophrenia
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2014)Schizophrenia (SCZ) is a severe and debilitating disorder and it has a worldwide prevalence estimated at approximately 1%. The underlying pathogenesis of SCZ is poorly understood and there is a great need for diagnostic ... -
Implications of cortical structure and connectivity in autism spectrum disorder
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2015)Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterised by early-onset deficits in social communication and interaction together with recurrent restricted repetitive behaviours (APA, 2013). Insights ...