Browsing Chemistry (Scholarly Publications) by Author "PASZKO, EDYTA"
Now showing items 1-3 of 3
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High content screening as high quality assay for biological evaluation of photosensitizers in vitro.
SENGE, MATHIAS; VAZ, GISELA MARGARIDA; PASZKO, EDYTA; DAVIES, ANTHONY (2013)A novel single step assay approach to screen a library of photdynamic therapy (PDT) compounds was developed. Utilizing high content analysis (HCA) technologies several robust cellular parameters were identified, which can ... -
Synthesis and biological evaluation of Foscan® bile acid conjugates to target esophageal cancer cells
SENGE, MATHIAS; PASZKO, EDYTA; MAJER, FERENC; GILMER, JOHN (2013)Porphyrins and chlorins such as Foscan? have a natural proclivity to accumulate in cancer cells. This trait has made them good candidates for photosensitizers and as imaging agents in phototherapy. In order to improve ... -
Transferrin conjugation does not increase the efficiency of liposomal Foscan during in vitro photodynamic therapy of oesophageal cancer
SENGE, MATHIAS; EHRHARDT, CARSTEN; PASZKO, EDYTA (2013)Photodynamic therapy (PDT) is based on the delivery of photocytotoxic agents to a target tissue, followed by irradiation. In order to increase the efficiency of PDT in oesophageal cancer therapy, polyethylene glycol ...