Browsing Chemistry (Theses and Dissertations) by Sponsor "Irish Research Council (IRC)"
Now showing items 1-20 of 27
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Assembly, disassembly and reassembly: New synthetic approaches towards hybrid, mixed-metal and framework materials
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2018)The research presented in this thesis focuses on the synthesis of novel examples of advanced materials. The project aimed to synthesise new examples of three particular classes of materials; namely organic-inorganic hybrid ... -
Cubane and Triptycene as Scaffolds in the Synthesis of Porphyrin Arrays
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2020)The primary aim of this research was to synthesise multichromophoric arrays that are linked through rigid isolating units with the capacity to arrange the chromophores in a linear and fixed orientation. The electronically ... -
Design, synthesis, and biochemical evaluation of guanidine-based derivatives targeting protein kinases
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2022)Kinases are some of the most intensively pursued classes of drug targets with approximately 243 distinct kinase inhibitors making it to human trials and most of these compounds are being investigated for the treatment of ... -
Development and Studies of New Magnetic Core@Shell Nanostructures
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2022)In this work, the synthesis of various magnetic nanoparticles such as magnetite, manganese ferrite, cobalt ferrite and copper ferrite is explored using different synthetic protocols. The produced nanomaterials are characterised ... -
Development of modified nucleosides for targeting the DNA repair enzyme SNM1A
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2022)Certain cancers exhibit upregulation of DNA interstrand crosslink repair pathways, which contributes to resistance to crosslinking chemotherapy drugs and poor prognoses. Inhibition of enzymes implicated in interstrand ... -
Development of Multimodal Magnetic-Plasmonic Nanocomposites
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2020)The main aim of this work was to prepare a wide range of magnetic-plasmonic nano- and micro-materials and to explore their properties and potential applications. The combination of both magnetic and plasmonic properties ... -
Electrochemical probing of the nanostructure of non-crystalline nitrogenated carbon materials for electrocatalysis
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2019)Carbon materials are applied in a variety of electrochemical applications including fuel cells, electrolyzers, batteries, supercapacitors and biosensors. The doping of carbon materials with heteroatoms such as nitrogen has ... -
Examination of the organocatalysed reactions between azides and cyclic anhydrides
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2022)Azide is encountered in organic synthesis as both a functional group and as and an ion, and provides a valuable means of incorporating nitrogen into target compounds. The intrinsic nucleophilicity of azides can be beneficial, ... -
Exploring the Diverse Landscape of Layered Double Hydroxide-Based Nanomaterials
(Trinity College Dublin. School of Chemistry. Discipline of ChemistryTrinity College Dublin, School of Chemistry, 2024)This thesis details the synthesis, characterisation, and an exploration of the diverse application landscape of layered double hydroxide (LDH)-based nanomaterials. The aim is to showcase the potential of LDHs in chirality ... -
Fluorescent probes to target nucleic acids
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2023)Guanine-quadruplexes (G-quadruplexes) are non-canonical nucleic acid structures that consist of two or more stacked G-tetrads further stabilized by monovalent-cations. These structures are stable under physiological ... -
Guanidine based derivatives as potential anti-infective agents: Tackling protozoal diseases and Mycobacterium tuberculosis
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2022)Infectious diseases caused by microorganisms of the genus Trypanosoma (Human African Trypanomiasis-HAT), Leishmania (Leishmaniasis), Plasmodium (Malaria) and Mycobacterium (Tuberculosis) cause some of the deadliest human ... -
Helium Ion Beam Irradiation of MoS2: Fabrication of 2D Memristors
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2020)A memristor is an electronic device which exhibits a non-volatile and reversible resistance change in response to an applied electric field. These properties make the memristor a potential prime component in the field of ... -
In search of strong light-harvesting and long-lived Ru (II) and Ir(III) triplet photosensitisers
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2018)The Ph.D. thesis begins with a general introduction of triplet photosensitisers and their role in Triplet-Triplet Annihilation Upconversion (TTA-UC). It gives a short literature review of the photophysical properties of ... -
The Interaction of Chiral Nanoparticles with Biological Objects
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2021)The main goal of this research is to investigate how different factors influence the induced optical activity of semiconductor nanoparticles (NPs) of various shapes and test the biological activity of NPs capped with chiral ... -
Investigation of the Structure-Property Relationships of Photoactive Surfactants
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2018)Surfactants are functional and versatile molecules, common to a plethora of industries and applications as emulsifying, wetting, dispersing and foaming agents. The usefulness of surfactants is a result of their amphiphilicity; ... -
Manganese Coordination Complexes: From Magnetism to Water Oxidation
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2020)Ever increasing energy demands and the closely related issue of global warming derived from fossil fuel combustion have encouraged the development of renewable energy sources and energy storage concepts as one of the most ... -
New Approaches to the treatment of Schizophrenia and other Neuropsychiatric Disorders: Targeting alpha2-adrenoceptors
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2019)Schizophrenia is a severe mental illness affecting 21 million people worldwide, resulting in cognitive impairments and negative symptoms that impact patients' ability to live a normal life. Almost all current antipsychotic ... -
New Materials for Controlled Singlet Oxygen Generation
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2021)Singlet oxygen is notoriously uncontrollable, suffers from poor selectivity, and has fast decomposition rates in biological media. Across the scientific community, there is an enduring effort to refine singlet oxygen ... -
Non-covalent interactions in supramolecular hybrid polyoxometalates
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2020)Polyoxometalates (POMs) are a species of discrete anionic polynuclear metal-oxo clusters made from early transition metals in their higher oxidation states. Together with organic ligands they can be assembled in hybrid ... -
PRINTED AND TEMPLATED 3D MXENE STRUCTURES FOR ENERGY STORAGE APPLICATIONS
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2023)Recently, MXenes have emerged as a promising family of materials for a variety of energy storage devices, with much of the work surrounding supercapacitors based on Ti3C2Tx. Nanosheets of this material combine a metallically ...
