Browsing Chemistry (Theses and Dissertations) by Author "Fay, Ellen"
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Nucleoside and Oligonucleotide Modification for Targeting the DNA Damage Repair Enzyme SNM1A
Fay, Ellen (Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2024)The exonuclease SNM1A is a key enzyme involved in the repair of interstrand crosslinks, a highly cytotoxic form of DNA damage. As cells depleted in this enzyme display increased sensitivity to chemotherapeutic agents such ...