Two-Photon Polymerization of Sugar Responsive 4D Microstructures
Citation:
Alexa Ennis, Deanna Nicdao, Srikanth Kolagatla, Luke Dowling, Yekaterina Tskhe, Alex J. Thompson, Daniel Trimble, Colm Delaney, Larisa Florea, Two-Photon Polymerization of Sugar Responsive 4D Microstructures, Advanced Functional Materials, 2023Download Item:
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Abstract:
Stimuli-responsive hydrogels have attracted much attention owing to the versatility of their programmed response in offering intelligent solutions for biomimicry applications, such as soft robotics, tissue engineering, and drug delivery. To achieve the complexity of biomimetic structures, two photon polymerization (2PP) has provided a means of fabricating intricate 3D structures from stimuli-responsive hydrogels. Rapid swelling hydrogel microstructures are advantageous for osmotically driven stimuli-response, where actuation speed, that is reliant on the diffusion of analytes or bioanalytes, can be optimized. Herein, the flexibility of 2PP is exploited to showcase a novel sugar-responsive, phenylboronic acid-based photoresist. This offers a remarkable solution for achieving fast response hydrogel systems that have been often hindered by the volume-dependent diffusion times of analytes to receptor sites. A phenylboronic acid-based photoresist compatible with 2PP is presented to fabricate stimuli-responsive microstructures with accelerated response times. Moreover, microstructures with programmable actuation (i.e., bending and opening) are fabricated using the same photoresist within a one-step fabrication process. By combining the flexibility of 2PP with an easily adaptable photoresist, an accessible fabrication method is showcased for sophisticated and chemo-responsive 3D hydrogel actuators.
Sponsor
Grant Number
Irish Research Council (IRC)
GOIPD/2020/484
Engineering and Physical Sciences Research Council (EPSRC)
EP/S023259/1
European Commission
899349
European Research Council (ERC)
802929
Engineering and Physical Sciences Research Council (EPSRC)
18/EPSRC-CDT-3581
Science Foundation Ireland (SFI)
18/EPSRC-CDT-3581
Science Foundation Ireland (SFI)
12/RC/2278_P2
Author's Homepage:
http://people.tcd.ie/florealDescription:
PUBLISHED
Author: Florea, Larisa
Type of material:
Journal ArticleCollections:
Series/Report no:
Advanced Functional Materials;Availability:
Full text availableSubject (TCD):
Nanoscience & Materials , Next Generation Medical Devices , Organic chemistry , Polymers , PolymersDOI:
10.1002/adfm.202213947Licences: