Browsing by Subject "Chondrogenesis"
Now showing items 1-7 of 7
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3D printing of fibre-reinforced cartilaginous templates for the regeneration of osteochondral defects
(2020)Successful osteochondral defect repair requires regenerating the subchondral bone whilst simultaneously promoting the development of an overlying layer of articular cartilage that is resistant to vascularization and ... -
Cell-matrix interactions regulate mesenchymal stem cell response to hydrostatic pressure
(2012)Both hydrostatic pressure (HP) and cell-matrix interactions have independently been shown to regulate the chondrogenic differentiation of mesenchymal stem cells (MSCs). The objective of this study was to test the hypothesis ... -
Dynamic compression can inhibit chondrogenesis of mesenchymal stem cells.
(2008)The objective of this study was to investigate the influence of dynamic compressive loading on chondrogenesis of mesenchymal stem cells (MSCs) in the presence of TGF-?3. Isolated porcine MSCs were suspended in 2% agarose ... -
Geometric analysis of chondrogenic self-organisation of embryonic limb bud cells in micromass culture.
(Springer Nature, 2022)Spatial and temporal control of chondrogenesis generates precise, species-specific patterns of skeletal structures in the developing vertebrate limb. The pattern-template is laid down when mesenchymal cells at the core ... -
Hypoxia mimicking hydrogels to regulate the fate of transplanted stem cells
(2019)Controlling the phenotype of transplanted stem cells is integral to ensuring their therapeutic efficacy. Hypoxia is a known regulator of stem cell fate, the effects of which can be mimicked using hypoxia-inducible factor ... -
Localization of YAP activity in developing skeletal rudiments is responsive to mechanical stimulation
(University of Edinburgh (datashare), 2020)Background: Normal skeletal development, in particular ossification, joint formation and shape features of condyles, depends on appropriate mechanical input from embryonic movement but it is unknown how such physical stimuli ... -
Mechanical Regulation of Skeletal Development
(University of Edinburgh (datashare), 2013)Development of the various components of a normal skeleton requires highly regulated signalling systems that co-ordinate spatial and temporal patterns of cell division, cell differentiation and morphogenesis. Much work in ...