Browsing by Author "Porter, Richard"
Now showing items 1-20 of 26
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2-Deoxy-D-Glucose inhibits aggressive triple-negative breast cancer cells by targeting glycolysis and the cancer stem cell phenotype
O'Driscoll, Lorraine; Porter, Richard (2019)Due to limited availability of pharmacological therapies, triple-negative breast cancer (TNBC) is the subtype with worst outcome. We hypothesised that 2-Deoxy-D-Glucose (2-DG), a glucose analogue, may hold potential as a ... -
Absence of Mitochondrial Uncoupling Protein 1 Affects Apoptosis in Thymocytes, Thymocyte/T-Cell profile and Peripheral T-Cell Number
Porter, Richard (Elsevier, 2010)Our laboratory has previously demonstrated the presence of constitutively expressed mitochondrial uncoupling protein 1 in mouse thymocytes. In our endeavours to understand the role of mitochondrial uncoupling protein 1 in ... -
Absence of mitochondrial uncoupling protein 3: Effect on thymus and spleen in the fed and fasted mice
Porter, Richard (2011)Mitochondrial uncoupling protein 3 (UCP3) is consituitively expressed in mitochondria from thymus and spleen of mice, and confocal microscopy has been used to visualize UCP3 in situ in mouse thymocytes. UCP3 is present ... -
Bioenergetics of acquired cisplatin resistant H1299 non-small cell lung cancer and P31 mesothelioma cells
Porter, Richard; Rooney, Mary (2017)Acquired cisplatin resistance is a common feature of tumours following cancer treatment with cisplatin and also of non-small cell lung cancer (H1299) and mesothelioma (P31) cell lines exposed to cisplatin. To elucidate the ... -
Control of Choline Oxidation in Rat Kidney Mitochondria
Porter, Richard (2009)Choline is a quaternary amino cationic organic alcohol that is oxidized to betaine in liver and kidney mitochondria. Betaine acts as an intracellular organic osmolyte in the medulla of the kidney. Evidence is provided that ... -
Effect of dietary restriction and subsequent realimentation on hepatic oxidative phosphorylation in cattle
Porter, Richard (2021)Compensatory growth (CG) is a naturally accelerated growth which occurs upon realimentation, following a prior period of dietary restriction. The process is harnessed worldwide as a management practice to reduce feed costs ... -
Excess visceral adiposity induces alterations in mitochondrial function and energy metabolism in esophageal adenocarcinoma.
O'Sullivan, Jacintha; Pidgeon, Graham; Reynolds, John; Porter, Richard; Lynam-Lennon, Niamh (2014)Background Visceral obesity has a strong association with both the incidence and mortality of esophageal adenocarcinoma (EAC). Alterations in mitochondrial function and energy metabolism is an emerging hallmark of cancer, ... -
Genotype variation at the MSTN locus is associated with skeletal muscle Coenzyme Q level in untrained Thoroughbred horses.
Porter, Richard (2019)In the finely-tuned athletic species of Thoroughbred horses, polymorphisms (Intro 1 SNP g.66493737C>T and SINE insertion 227bp in promoter) in the myostatin gene (MSTN), a pronounced inhibitor of skeletal muscle growth, ... -
Identification of a functioning mitochondrial uncoupling protein 1 in thymus
Fallon, Padraic; Porter, Richard (2005)We present evidence that rat and mouse thymi contain mitochondrial uncoupling protein (UCP 1). Reverse transcriptase-PCR detected RNA transcripts for UCP 1 in whole thymus and in thymocytes. Furthermore, using antibodies ... -
Images of mitochondrial UCP 1 in mouse thymocytes using confocal microscopy
Voorheis, Howard; Fallon, Padraic; Porter, Richard; Nolan, Derek (2008)The aim of this study was to demonstrate the constitutive expression of mitochondrial uncoupling protein 1 (UCP 1) in pure thymocytes using laser scanning confocal microscopic imagery. To that end we probed thymocytes from ... -
Lack of activation of UCP1 in isolated brown adipose tissue mitochondria by glucose-O-ω-modified saturated fatty acids of various chain lengths.
Porter, Richard (2013)We previously demonstrated that uncoupling protein 1 activity, as measured in isolated brown adipose tissue mitochondria (and as a native protein reconstituted into liposome membranes), was not activated by the non-flippable ... -
Mitochondrial abundance and function in skeletal muscle and liver from Simmental beef cattle divergent for residual feed intakee
Porter, Richard (2020)Cellular mitochondrial function has been suggested to contribute to variation in feed efficiency (FE) among animals. The objective of this study was to determine mitochondrial abundance and activities of various mitochondrial ... -
Mitochondrial physiology.
Porter, Richard (2020)As the knowledge base and importance of mitochondrial physiology to human health expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. ... -
Mitochondrial uncoupling protein 1 expression in thymocytes.
Fallon, Padraic; Porter, Richard (2008)Using an antibody specific and selective to mitochondrial uncoupling protein 1 (UCP1) peptide, this study confirms the observation that UCP 1 is present in thymocytes isolated from UCP 1 wild-type, but not UCP 1 knock-out ... -
MSTN genotype variation affects skeletal muscle mitochondrial abundance and fibre composition in untrained Thoroughbred horses,
Porter, Richard; Rooney, Mary (2016) -
Neuromedin U alters bioenergetics and expands the cancer stem cell phenotype in HER2-positive breast cancer
O'Driscoll, Lorraine; Porter, Richard; Martinez, Vanesa G.; Crown, John (2017)Neuromedin U (NmU) is a neuropeptide belonging to the neuromedin family. Recently, we reported a significant association between NmU and breast cancer, particularly correlating with increased aggressiveness, resistance to ... -
The peripheral cannabinoid receptor type 1 (CB1) as a molecular target for modulating body weight in man
Porter, Richard (2021)The cannabinoid 1 (CB1) receptor regulates appetite and body weight; however, unwanted central side effects of both agonists (in wasting disorders) or antagonists (in obesity and diabetes) have limited their therapeutic ... -
The Preservation of in vivo Phosphorylated and Activated Uncoupling Protein 3 (UCP3) in Isolated Skeletal Muscle Mitochondria following Administration of 3,4-Methylenedioxymethamphetamine (MDMA aka Ecstasy) to Rats/Mice
Meegan, Mary; Porter, Richard (2012)Previous researchers have demonstrated that 3,4-methylenedioxymethamphetamine (MDMA) induced hyperthermia, in skeletal muscle of animals, is uncoupling protein 3 (UCP3) dependent. In light of our investigations that in ... -
Pro-inflammatory Stimulation of Monocytes by ANCA Is Linked to Changes in Cellular Metabolism
Porter, Richard (2020)Clinical and experimental data suggest that pathogenesis in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis is driven by ANCA-mediated activation of neutrophils and monocytes. While the role of neutrophils ... -
Prolonged oral coenzyme Q10-β-cyclodextrin supplementation increases skeletal muscle complex I+III activity in young Thoroughbreds
Rooney, Mary; Porter, Richard (2020)In summary, this study demonstrated that oral supplemen- tation of young, healthy untrained Thoroughbreds on a pasture and oat diet with a CoQ 10 -β-cyclodextrin inclusion complex via syringe significantly increased ...