Browsing by Author "Panoskaltsis, Nicki"
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Chemotherapy drug scheduling for the induction treatment of patients with acute myeloid leukemia
Panoskaltsis, Nicki (2014)Leukemia is an immediately life-threatening cancer wherein immature blood cells are overproduced, accumulate in the bone marrow (BM) and blood and causes immune and blood system failure. Treatment with chemotherapy can ... -
The development of a three-dimensional scaffold for ex vivo biomimicry of human acute myeloid leukaemia
Panoskaltsis, Nicki (2010)Acute myeloid leukaemia (AML) is a cancer of haematopoietic cells that develops in three-dimensional (3-D) bone marrow niches in vivo. The study of AML has been hampered by lack of appropriate ex vivo models that mimic ... -
Dynamic human erythropoiesis in a three-dimensional perfusion bone marrow biomimicry
Mantalaris, Athanasios; Panoskaltsis, Nicki (2019)Traditional culture systems for human erythropoiesis lack microenvironmental niches, spatial marrow gradients and dense cellularity rendering them incapable of effectively translating marrow physiology ex vivo. Herein, a ... -
Long-term cytokine-free expansion of cord blood mononuclear cells in three-dimensional scaffolds
Panoskaltsis, Nicki; Mantalaris, Athanasios (2011)Cord blood expansion ex vivo can be achieved in liquid suspension through the addition of cytokines at the expense of often undesirable cell differentiation. In order to derive a cytokine-free dynamic culture system, we ...