Browsing by Author "O'LEARY, JOHN"
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Aspirin and P2Y<inf>12</inf> inhibition attenuate platelet-induced ovarian cancer cell invasion
SHEILS, ORLA; O'LEARY, JOHN; SPILLANE, CATHY (2015)Background: Platelet-cancer cell interactions play a key role in successful haematogenous metastasis. Disseminated malignancy is the leading cause of death among ovarian cancer patients. It is unknown why different ovarian ... -
Carboplatin and taxol resistance develops more rapidly in functional BRCA1 compared to dysfunctional BRCA1 ovarian cancer cells
O'TOOLE, SHARON; O'LEARY, JOHN; BUSSCHOTS, STEVEN (2014)A major risk factor for ovarian cancer is germline mutations of BRCA1/2. It has been found that (80%) of cellular models with acquired platinum or taxane resistance display an inverse resistance relationship, that is ... -
Catching moving targets: Cancer stem cell hierarchies, therapy-resistance & considerations for clinical intervention
O'LEARY, JOHN; Gasch, Claudia; Ffrench, Brendan; O'Leary, John J.; Gallagher, Michael F. (2017)It is widely believed that targeting the tumour-initiating cancer stem cell (CSC) component of malignancy has great therapeutic potential, particularly in therapy-resistant disease. However, despite concerted efforts, ... -
Correlation of p16(INK4A) expression and HPV copy number with cellular FTIR spectroscopic signatures of cervical cancer cells.
MARTIN, CARA; O'LEARY, JOHN (2011)Cervical cancer, a potentially preventable disease, has its main aetiology in infection by high risk human papillomavirus (HR-HPV). Approaches to improving cervical cancer screening and diagnostic methodologies include ... -
Developing ovarian cancer stem cell models: laying the pipeline from discovery to clinical intervention.
O'LEARY, JOHN; GALLAGHER, MICHAEL (2014)Despite decades of research, ovarian cancer is still associated with unacceptably high mortality rates, which must be addressed by novel therapeutic approaches. One avenue through which this may be achieved is targeting ... -
Endosomal gene expression: a new indicator for prostate cancer patient prognosis?
O'LEARY, JOHN; KEEGAN, HELEN; SPILLANE, CATHY (2015)Prostate cancer continues to be a major cause of morbidity and mortality in men, but a method for accurate prognosis in these patients is yet to be developed. The recent discovery of altered endosomal biogenesis in prostate ... -
Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy
O'NEILL, LUKE; O'LEARY, JOHN (2017)The imminent threat of viral epidemics and pandemics dictates a need for therapeutic approaches that target viral pathology irrespective of the infecting strain. Reactive oxygen species are ancient processes that ... -
Evaluation of the clinical performance of the cobas 4800 HPV test in patients referred for colposcopy.
O'TOOLE, SHARON; PILKINGTON, LORETTO; MARTIN, CARA; O'LEARY, JOHN; KEEGAN, HELEN (2013)The clinical performance of the cobas human papillomavirus (HPV) test for detection of high-grade disease in a colposcopy-referred population was compared with that of Hybrid Capture 2 (HC2). The overall agreement between ... -
Generation and characterisation of Cisplatin-resistant non-small cell lung cancer cell lines displaying a stem-like signature.
BARR, MARTIN; O'LEARY, JOHN; GRAY, STEVEN (2013)Introduction: Inherent and acquired cisplatin resistance reduces the effectiveness of this agent in the management of non- small cell lung cancer (NSCLC). Understanding the molecular mechanisms underlying this process ... -
Hands-free sample preparation platform for nucleic acid analysis.
MARTIN, CARA; KEEGAN, HELEN; O'LEARY, JOHN (2009)A Lab-On-Chip system with an instrument is presented which is capable of performing total sample preparation and automated extraction of nucleic acid from human cell samples fixed in a methanol based solution. The target ... -
Identifying novel hypoxia-associated markers of chemoresistance in ovarian cancer
SHEILS, ORLA; O'LEARY, JOHN; GALLAGHER, MICHAEL; SPILLANE, CATHY (2015)Background: Ovarian cancer is associated with poor long-term survival due to late diagnosis and development of chemoresistance. Tumour hypoxia is associated with many features of tumour aggressiveness including increased ... -
"If you can't treat HPV, why test for it?" Women's attitudes to the changing face of cervical cancer prevention: A focus group study
O'LEARY, JOHN (2014)Open Access Research article “If you can’t treat HPV, why test for it?” Women’s attitudes to the changing face of cervical cancer prevention: a focus group study Judith McRae1*, Cara Martin2, John O’Leary3, Linda Sharp1 ... -
An integrated analysis of the SOX2 microRNA response program in human pluripotent and nullipotent stem cell lines.
SHEILS, ORLA; O'LEARY, JOHN; GALLAGHER, MICHAEL; SPILLANE, CATHY (2014) -
Molecular testing in oncology: Problems, pitfalls and progress.
FINN, STEPHEN; O'LEARY, JOHN (2014)Recent advances in the understanding of the molecular basis of cancer and the development of molecular diagnostics based on this knowledge have done much to progress the fields of oncology and pathology. Technological ... -
Motivators for women to attend cervical screening: The influential role of GPs
O'LEARY, JOHN (2014)Background. Participation in organized cervical cancer screening has declined recently. While research has focussed on barriers to screening participation, less attention has been paid to what motivates women to attend. ... -
The MyD88+ Phenotype Is an Adverse Prognostic Factor in Epithelial Ovarian Cancer.
O'NEILL, LUKE; GLEESON, NOREEN; O'TOOLE, SHARON; O'BYRNE, KEN; O'LEARY, JOHN; SMYTH, PAUL (2014)The prognosis of epithelial ovarian cancer is poor in part due to the high frequency of chemoresistance. Recent evidence points to the Toll-like receptor-4 (TLR4), and particularly its adaptor protein MyD88, as one potential ... -
The MyD88+ phenotype is an adverse prognostic factor in epithelial ovarian cancer.
MARTIN, CARA; SHEILS, ORLA; SMYTH, PAUL; FINN, STEPHEN; O'LEARY, JOHN; GALLAGHER, MICHAEL; BATES, MARK; SPILLANE, CATHY (2014)The prognosis of epithelial ovarian cancer is poor in part due to the high frequency of chemoresistance. Recent evidence points to the Toll-like receptor-4 (TLR4), and particularly its adaptor protein MyD88, as one potential ... -
Non-invasive and non-destructive measurements of confluence in cultured adherent cell lines
O'LEARY, JOHN (2015)Many protocols used for measuring the growth of adherent monolayer cells in vitro are invasive, destructive and do not allow for the continued, undisturbed growth of cells within flasks. Protocols often use indirect methods ... -
Platelet Adhesion and Degranulation Induce Pro-Survival and Pro-Angiogenic Signalling in Ovarian Cancer Cells
SMYTH, PAUL; O'LEARY, JOHN; O'TOOLE, SHARON; SPILLANE, CATHY; MARTIN, CARA; GALLAGHER, MICHAEL; NORRIS, LUCY; CONLON, NIAMH; MCEVOY, LYNDA MARIE; FFRENCH, GEORGE BRENDAN; STORDAL, BRITTA; KEEGAN, HELEN; FINN, STEPHEN; MCENEANEY, VICTORIA; SHEILS, ORLA; CROWLEY, DARRAGH (2011)Thrombosis is common in ovarian cancer. However, the interaction of platelets with ovarian cancer cells has not been critically examined. To address this, we investigated platelet interactions in a range of ovarian cancer ... -
Prevalence of human papillomavirus in men who have sex with men in the era of an effective vaccine; a call to act.
SMYTH, PAUL; O'LEARY, JOHN; SHEILS, ORLA (2014)OBJECTIVES: The incidence of human papillomavirus (HPV)-associated anal cancer is increasing. Men who have sex with men (MSM), particularly those coinfected with HIV, are disproportionately affected. Documenting the ...