Browsing by Author "Mc Manus, Ross"
Now showing items 1-20 of 28
- Sort by:
- title
- issue date
- submit date
- Order:
- ascending
- descending
- Results:
- 5
- 10
- 20
- 40
- 60
- 80
- 100
-
Characterising cytokine gene expression signatures in patients with severe sepsis
Ryan, Thomas; Kelleher, Dermot; Mc Manus, Ross (2013)Introduction. Severe sepsis in humans may be related to an underlying profound immune suppressive state. We investigated the link between gene expression of immune regulatory cytokines and the range of illness severity in ... -
Coagulopathy After Cardiac Surgery May Be Influenced by a Functional Plasminogen Activator Inhibitor Polymorphism
Mc Manus, Ross; Kelleher, Dermot; Ryan, Thomas (2007)BACKGROUND: Cytokine-mediated inflammation and coagulopathy may occur after cardiac surgery. In this study we investigated the temporal pattern of plasminogen activator inhibitor-1 (PAI-1) gene expression after cardiac ... -
Common polygenic variation in coeliac disease and confirmation of ZNF335 and NIFA as disease susceptibility loci
Corvin, Aiden; Mc Manus, Ross; Kelleher, Dermot; Trimble, Valerie; Kennedy, Nicholas (2016)Coeliac disease (CD) is a chronic immune-mediated disease triggered by the ingestion of gluten. It has an estimated prevalence of approximately 1% in European populations. Specific HLA-DQA1 and HLA-DQB1 alleles are established ... -
Comprehensive assessment of rheumatoid arthritis susceptibility loci in a large psoriatic arthritis cohort
Mc Manus, Ross; Kane, David (2012)Objective: A number of rheumatoid arthritis (RA) susceptibility genes have been identified in recent years. Given the overlap in phenotypic expression of synovial joint inflammation between RA and psoriatic arthritis (PsA), ... -
Conditional analysis identifies three novel major histocompatibility complex loci associated with psoriasis
Mc Manus, Ross; Irvine, Alan (2012)Psoriasis is a common, chronic, inflammatory skin disorder. A number of genetic loci have been shown to confer risk for psoriasis. Collectively, these offer an integrated model for the inherited basis for susceptibility to ... -
Confirmation of TNIP1 and IL23A as susceptibility loci for psoriatic arthritis
Kane, David; Mc Manus, Ross; Bowes, John; Orozco, Gisela; Flynn, Edward; Ho, Pauline; Brier, Rasha; Marzo-Ortega, Helena; Coates, Laura; Ryan, Anthony W.; Korendowych, Eleanor; McHugh, Neil; Fitzgerald, Oliver; Packham, Jonathan; Morgan, Ann W.; Bruce, Ian N.; Barton, Anne (2011)Objectives: To investigate a shared genetic aetiology for skin involvement in psoriasis and psoriatic arthritis (PsA) by genotyping single-nucleotide polymorphisms (SNPs), reported to be associated in genome-wide ... -
Cross phenotype association mapping of the MHC identifies genetic variants that differentiate psoriatic arthritis from psoriasis
Mc Manus, Ross; Kane, David (2017)Objectives: Psoriatic arthritis (PsA) is a chronic inflammatory arthritis, with a strong heritable component, affecting patients with psoriasis. Here we attempt to identify genetic variants within the major histocompatibility ... -
Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis
Mc Manus, Ross; Kane, David (2015)Poriatic arthritis (PsA) is a chronic inflammatory arthritis associated with psoriasis and, despite the larger estimated heritability for PsA, the majority of genetic susceptibility loci identified to date are shared ... -
Dietary fat, abdominal obesity and smoking modulate the relationship between plasma complement component 3 concentrations and metabolic syndrome risk
Mc Manus, Ross (2012)Objective: Chronic inflammation plays a role in the pathogenesis of metabolic syndrome (MetS) and cardiovascular disease (CVD). Complement component 3 (C3) is a novel cardiometabolic risk factor. Whether dietary fat intake ... -
Evaluation of 6 candidate genes on chromosome 11q23 for coeliac disease susceptibility: a case control study
Feighery, Conleth; Trimble, Valerie; Kennedy, Nicholas; Mc Manus, Ross; Kelleher, Dermot; O'Morain, Colm (2010)BACKGROUND: Recent whole genome analysis and follow-up studies have identified many new risk variants for coeliac disease (CD, gluten intolerance). The majority of newly associated regions encode candidate genes with a ... -
Evidence to support IL-13 as a risk locus for psoriatic arthritis but not psoriasis vulgaris.
Mc Manus, Ross; Kane, David (2011)OBJECTIVE: /st> There is great interest in the identification of genetic factors that differentiate psoriatic arthritis (PsA) from psoriasis vulgaris (PsV), as such discoveries could lead to the identification of distinct ... -
A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21
Mc Manus, Ross; Feighery, Conleth; Kelleher, Dermot (2007)We tested 310,605 single-nucleotide polymorphisms for association in 778 celiac disease cases and 1422 controls. Outside the HLA, the most significant finding (rs13119723, P=2.0 ? 10?7, empirical genome-wide significance ... -
Human peripheral and gastric lymphocyte responses to Helicobacter pylori NapA and AphC differ in infected and uninfected individuals
Mc Manus, Ross; Kelleher, Dermot; Windle, Henry (2005)BACKGROUND: In this study, we identify the nature of the immunological response of human peripheral blood mononuclear cells (PBMC) and lamina propria gastric lymphocytes (LPL) to two Helicobacter pylori antigens, the ... -
Increased Population Risk of AIP-related Acromegaly and Gigantism in Ireland
Mc Manus, Ross (2017)The aryl hydrocarbon receptor interacting protein (AIP) founder mutation R304* (or p.R304*; NM_003977.3:c.910C>T, p.Arg304Ter) identified in Northern Ireland (NI) predisposes to acromegaly/gigantism; its population health ... -
Meta-Analysis of Genome-Wide Association Studies in Celiac Disease and Rheumatoid Arthritis Identifies Fourteen Non-HLA Shared Loci.
Mc Manus, Ross (2011)Epidemiology and candidate gene studies indicate a shared genetic basis for celiac disease (CD) and rheumatoid arthritis (RA), but the extent of this sharing has not been systematically explored. Previous studies demonstrate ... -
Multiple common variants for celiac disease influencing immune gene expression
Mc Manus, Ross; Kelleher, Dermot (2010)We performed a second-generation genome-wide association study of 4,533 individuals with celiac disease (cases) and 10,750 control subjects. We genotyped 113 selected SNPs with P(GWAS) < 10(-4) and 18 SNPs from 14 known ... -
Myeloid KLF2 Regulates the Host Response to Polymicrobial Infection and Endotoxic Shock
Mc Manus, Ross (2011)Precise control of myeloid cell activation is required for optimal host defense. However, this activation process must be under exquisite control to prevent uncontrolled inflammation. Herein, we identify the Kruppel-like ... -
Newly identified genetic risk variants for celiac disease related to the immune response.
O'Morain, Colm; Kennedy, Nicholas; Kelleher, Dermot; Mc Manus, Ross (2008) -
NF-κB regulation: The nuclear response
Mc Manus, Ross; Gray, Steven; Kelleher, Dermot (2009)Nuclear factor ?B (NF-?B) is an inducible transcription factor that tightly regulates the expression of a large cohort of genes. As a key component of the cellular machinery NF-?B is involved in a wide range of biological ... -
Polymorphisms Near TBX5 and GDF7 Are Associated With Increased Risk for Barrett's Esophagus.
O'Sullivan, Jacintha; Reynolds, John; Mc Manus, Ross (2015)Barrett ’ s esophagus (BE) increases the risk of esophageal adenocarcinoma (EAC). We found the risk to be BE has been associated with single nucleotide polymorphisms (SNPs) on chromosome 6p21 (within the HLA region) ...