Browsing by Author "MCCABE, THOMAS"
Now showing items 1-9 of 9
-
{4,6-Bis[(E)-1-methyl-2-(pyridin-2-yl-methyl-idene-κN)hydrazinyl-κN]pyrimidine-κN}dichloridocopper(II) methanol disolvate monohydrate
MCCABE, THOMAS; SCHMITT, WOLFGANG; MARZEC, BARTOSZ (2011)The title compound, [CuCl2(C18H18N8)]?2CH3OH?H2O, contains a pentacoordinated Cu(II) atom bonded to the tridentate 4,6-bis[(E)-1-methyl-2-(pyridin-2-ylmethylidene)hydrazinyl]pyrimidine ligand and two Cl atoms. The geometry ... -
Colorimetric sensing of anions in aqueous solution using a charge neutral, cleft-like, amidothiourea receptor: Tilting the balance between hydrogen bonding and deprotonation in anion recognition
GUNNLAUGSSON, THORFINNUR; DUKE, REBECCA MONICA; O'BRIEN, JOHN; MCCABE, THOMAS (2008)The design, synthesis and physical evaluation of 1, a visible colorimetric `naked eye? pyridyl based bis-amidothiourea sensor for anions, is described. This charge neutral sensor gives rise to significant changes in the ... -
Crystallographic, 1H NMR and CD studies of sterically strained thiourea anion receptors possessing two stereogenic centres
GUNNLAUGSSON, THORFINNUR; QUINN, SUSAN; KRUGER, PAUL; MCCABE, THOMAS (2009)The synthesis and structural characterisation of three chiral bis-naphthalene thiourea receptors (1?3) derived from (R)-(+)-1-(1-naphthyl)ethylamine and (S)-(?)-1-(1-naphthyl)ethylamine are reported along with spectroscopic ... -
From thioether substituted porphyrins to sulfur linked porphyrin dimers: An unusual SNAr via thiolate displacement?
SENGE, MATHIAS; MCCABE, THOMAS; RYAN, AOIFE; PLUNKETT, SHANE (2014)Treatment of meso 2-ethylhexyl-3-mercaptopropionate substituted porphyrins with base at room temperature generated a porphyrin thiolate anion which in situ reacted in a nucleophilic aromatic substitution (SNAr) reaction ... -
Lanthanide directed self-assembly formations of Tb(iii) and Eu(iii) luminescent complexes from tryptophan based pyridyl amide ligands
GUNNLAUGSSON, THORFINNUR; MCCABE, THOMAS (2011)The formation of self-assembly complexes between the ligands 1 (SS) and 2 (RR) and terbium or europium was undertaken and shown (using various spectroscopic titrations) to give rise to the exclusive formation of 2 : 1 (L ... -
Substituted dipyridophenazine complexes of Cr(III): synthesis, enantiomeric resolution and binding interactions with calf thymus DNA.
KELLY, JOHN; MCCABE, THOMAS (2010)[Cr(phen)2(X2dppz)]3+ {X = H, Me, or F} have been synthesised, characterised, and chromatographically resolved into their constituent ? and ? enantiomers. The DNA-binding interactions of each of the racemic complexes were ... -
Synthesis and antiproliferative action of a novel series of maprotiline analogues
MEEGAN, MARY; MCCABE, THOMAS (2014)The synthesis of a diverse library of compounds structurally related to maprotiline, a norepinephrine reuptake transporter (NET) selective antidepressant which has recently been identified as a novel in vitro antiproliferative ... -
Synthesis and evaluation of azetidinone analogues of combretastatin A-4 as tubulin targeting agents
LLOYD, DAVID; NATHWANI, SEEMA; MCCABE, THOMAS; MEEGAN, MARY; GREENE, LISA; O'BOYLE, NIAMH; ZISTERER, DANIELA (2010) -
Synthesis, evaluation and structural studies of antiproliferative tubulin-targeting azetidin-2-ones
MEEGAN, MARY; GREENE, LISA; O'BOYLE, NIAMH; MCCABE, THOMAS; ZISTERER, DANIELA; LLOYD, DAVID (2011)A series of azetidin-2-ones substituted at positions 2, 3 and 4 of the azetidinone ring scaffold were synthesised and evaluated for antiproliferative, cytotoxic and tubulin binding activity. In these compounds, the cis ...