Browsing by Author "MARTIN, CARA"
Now showing items 1-9 of 9
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Epitope presentation is an important determinant of the utility of antigens identified from protein arrays in the development of autoantibody diagnostic assays
MARTIN, CARA; O'LEARY, JOHN JAMES; SHEILS, ORLA; MURPHY, MAIREAD; O'TOOLE, SHARON (Elsevier, 2012)Autoantibodies represent an attractive biomarker for diagnostic assays principally due to the stability of immunoglobulin in patient serum facilitating measurement with conventional assays. Immune responses to tumorigenesis ... -
Hands-free sample preparation platform for nucleic acid analysis.
MARTIN, CARA; KEEGAN, HELEN; O'LEARY, JOHN (2009)A Lab-On-Chip system with an instrument is presented which is capable of performing total sample preparation and automated extraction of nucleic acid from human cell samples fixed in a methanol based solution. The target ... -
The MyD88+ phenotype is an adverse prognostic factor in epithelial ovarian cancer.
MARTIN, CARA; SHEILS, ORLA; SMYTH, PAUL; FINN, STEPHEN; O'LEARY, JOHN; GALLAGHER, MICHAEL; BATES, MARK; SPILLANE, CATHY (2014)The prognosis of epithelial ovarian cancer is poor in part due to the high frequency of chemoresistance. Recent evidence points to the Toll-like receptor-4 (TLR4), and particularly its adaptor protein MyD88, as one potential ... -
Potential role of miR-9 and miR-223 in recurrent ovarian cancer
SHEILS, ORLA; O'LEARY, JOHN JAMES; O'TOOLE, SHARON; MARTIN, CARA (2008)Background: MicroRNAs (miRNAs) are small, noncoding RNAs that negatively regulate gene expression by binding to target mRNAs. miRNAs have not been comprehensively studied in recurrent ovarian cancer, yet an incurable ... -
Regulation of microRNA biosynthesis and expression in 2102Ep embryonal carcinoma stem cells is mirrored in ovarian serous adenocarcinoma patients.
SMYTH, PAUL; MARTIN, CARA; MCINERNEY, JAMIE KEVIN; ELBARUNI, SALAH AMRU; O'LEARY, JOHN; SALLEY, YVONNE; VENCKEN, SEBASTIAN; O'TOOLE, SHARON; AHERNE, SINEAD; SHEILS, ORLA; GALLAGHER, MICHAEL (2009)Background: Tumours with high proportions of differentiated cells are considered to be of a lower grade to those containing high proportions of undifferentiated cells. This property may be linked to the differentiation ... -
TLR9 provokes inflammation in response to fetal DNA: mechanism for fetal loss in preterm birth and preeclampsia.
O'LEARY, JOHN; MARTIN, CARA; O'NEILL, LUKE; DOYLE, BRENDAN; ABRAHAMSON, DAVID; CORR, SINEAD; CARPENTER, SUSAN (2012)