Browsing by Subject "Immunology"
Now showing items 21-40 of 136
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Characterising Cytokine Gene Expression Signatures in Patients with Severe Sepsis
(2013)Introduction. Severe sepsis in humans may be related to an underlying profound immune suppressive state. We investigated the link between gene expression of immune regulatory cytokines and the range of illness severity in ... -
Clumping factor A interaction with complement factor I increases C3b cleavage on the bacterial surface of Staphylococcus aureus, and decreases complement-mediated phagocytosis
(2010)The human complement system is important in the immunological control of Staphylococcus aureus infection. We showed previously that S. aureus surface protein clumping factor A (ClfA), when expressed in recombinant form, ... -
The co-ordination of T cell function by Serine/threonine kinases
(2011)The function of T-lymphocytes during adaptive immune responses is directed by antigen receptors, costimulatory molecules, and cytokines. These extrinsic stimuli are coupled to a network of serine/threonine kinases that ... -
Counter-regulation in the IKK family.
(2011)The human IKK [I?B (inhibitor of NF-?B) kinase] family has four members; they are the central kinases of innate immunity. Two members, IKK? and IKK?, the so-called canonical members, phosphoryate I?B?, leading to activation ... -
Crystallization of an engineered RUN domain of Rab6-interacting protein 1/DENND5.
(International Union of Crystallography, 2011)Effectors of the Rab small GTPases are large multi-domain proteins which have proved difficult to express in soluble form in Escherichia coli. Generally, effectors are recruited to a distinct subcellular compartment by ... -
The Cytokine Release Inhibitory Drug CRID3 Targets ASC Oligomerisation in the NLRP3 and AIM2 Inflammasomes
(2011)BACKGROUND: The Inflammasomes are multi-protein complexes that regulate caspase-1 activation and the production of the pro-inflammatory cytokine IL-1?. Previous studies identified a class of diarylsulfonylurea containing ... -
Defining the role of RORα in the functionality of distinct immune cell populations
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)The transcription factor Retinoic acid-related Orphan Receptor (ROR)-a has roles in metabolism, circadian rhythm and cellular development, such as Th17 cells and group 2 innate lymphoid cells (ILC2). The identification ... -
Detection of a Tyrosine Phosphatase LAR on Intestinal Epithelial Cells and Intraepithelial Lymphocytes in the Human Duodenum.
(Hindawi, 2005)Studies of tyrosine phosphorylation in the human duodenum have indicated that proliferating cells in the middle portion of the duodenal crypt were devoid of this feature, suggesting that tyrosine kinase activation is not ... -
The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility.
(Nature, 2011)Deubiquitinating enzymes are now emerging as potential therapeutic targets that control many cellular processes, but few have been demonstrated to control cell motility. Here, we show that ubiquitin-specific protease 17 ... -
Differential antimicrobial peptide gene expression patterns during early chicken embryological development
(2009)The adaptive immune system is not completely developed when chickens hatch, so the innate immune system has evolved a range of mechanisms to deal with early pathogenic assault. Avian b-defensins (AvBDs) and cathelicidins ... -
Differential Expression of NK Receptors CD94 and NKG2A by T Cells in Rheumatoid Arthritis Patients in Remission Compared to Active Disease
(2011)Objective: TNF inhibitors (TNFi) have revolutionised the treatment of rheumatoid arthritis (RA). Natural killer (NK) cells and Natural Killer Cell Receptor+ T (NKT) cells comprise important effector lymphocytes whose ... -
Distinct and Overlapping Effector Functions of Expanded Human CD4, CD8? and CD4CD8? Invariant Natural Killer T Cells
(2011)CD1d-restricted invariant natural killer T (iNKT) cells have diverse immune stimulatory/regulatory activities through their ability to release cytokines and to kill or transactivate other cells. Activation of iNKT cells ... -
DNA MICROARRAY GENOTYPING AND VIRULENCE AND ANTIMICROBIAL RESISTANCE GENE PROFILING OF METHICILLIN-RESISTANT Staphylococcus aureus BLOODSTREAM ISOLATES FROM RENAL PATIENTS
(2011)Thirty-six methicillin-resistant Staphylococcus aureus (MRSA) bloodstream isolates from renal patients were genetically characterized by DNA microarray analysis and spa typing. The isolates were highly clonal, belonging ... -
Effect of intranasal administration of Semliki Forest virus recombinant particles expressing interferon-? on the progression of experimental autoimmune encephalomyelitis.
(Spandidos, 2008)The effect of intranasal (IN) administration of Semliki Forest virus (SFV) recombinant particles expressing interferon-? [IFN-?, a partially effective treatment for multiple sclerosis (MS)] on the progression of experimental ... -
The emerging role of metabolic regulation in the functioning of Toll-like receptors and the NOD-like receptor Nlrp3
(Elsevier, 2011)While it has long been suspected that inflammation participates in the pathogenesis of metabolic disorders such as the insulin resistance that occurs in type 2 diabetes, recent work suggests that this is not the only ... -
Engineering innate immunology in cardiovascular disease models and regenerative medicine
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2023)Heart failure is the leading cause of death worldwide with atherosclerosis and myocardial infarction remaining prominent causes. It is now widely accepted that the inflammatory response holds a key role in advancing both ... -
Enriched CD141+ DCs in the joint are transcriptionally distinct, activated, and contribute to joint pathogenesis.
(2018)CD141+ DC are implicated in antiviral and antitumor immunity. However, mechanisticstudies in autoimmune disease are limited. This is the first study to our knowledgeexamining CD141+ DC in autoimmune disease, specifically ... -
Epitope presentation is an important determinant of the utility of antigens identified from protein arrays in the development of autoantibody diagnostic assays
(Elsevier, 2012)Autoantibodies represent an attractive biomarker for diagnostic assays principally due to the stability of immunoglobulin in patient serum facilitating measurement with conventional assays. Immune responses to tumorigenesis ... -
Evaluating the role of Toll-like Receptors in diseases of the Central Nervous system
(2011)A key part of the innate immune system is a network of pattern recognition receptors (PRRs) and their associated intracellular signalling pathways. Toll-like receptors (TLRs) are one such group of PRRs that detect pathogen ...