Browsing by Author "O'Driscoll, Lorraine"
Now showing items 21-40 of 72
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Expanding on Exosomes and Ectosomes in Cancer
O'Driscoll, Lorraine (2015) -
Extracellular vesicle separation from milk and infant milk formula using acid precipitation and ultracentrifugation
O'Driscoll, Lorraine (2021)Separation of highly enriched extracellular vesicles (EVs) fractions from milk is desirable for quantification, cargo analysis, functional characterization, and investigation as delivery vehicles for nutrients and/or ... -
Extracellular vesicles and anti-cancer drug resistance
O'Driscoll, Lorraine; McNamee, Niamh (2018)Extracellular vesicles (EVs) including exosomes, microvesicles, oncosomes, and microparticles have been associated with communicating anti-cancer drug-resistance. The in vitro, pre-clinical in vivo and patients' data linking ... -
Extracellular Vesicles From Mesenchymal Stem Cells as a Covid-19 Treatment
O'Driscoll, Lorraine (2020) -
Extracellular vesicles in blood: are they viable as diagnostic and predictive tools in breast cancer?
O'Driscoll, Lorraine (2020)Extracellular vesicles (EVs), often described as mini-maps of their cells of origin, are found in the bloodstream and can be rich sources of cargo released from cancer cells. As such, they could be collected through minimally ... -
Extracellular vesicles report on the MET status of their cells of origin regardless of the method used for their isolation.
Moran, Barry; O'Driscoll, Lorraine (2020)MET pathway is an important actionable target across many solid tumour types and several MET inhibitors have been developed. Extracellular vesicles (EVs) are proposed to be mini-maps of their cells of origin. However, the ... -
The future of Extracellular Vesicles as Theranostics - an ISEV meeting report
O'Driscoll, Lorraine; Soekmadji, Carolina; Li, Bo; Huang, Yiyao; Wang, Haifang; An, Taixue; Liu, Chunchen; Pan, Weilun; Chen, Jing; Cheung, Lesley; Falcon-Perez, Juan Manuel; Gho, Yong Song; Holthofer, Harry B.; Le, Minh T.N.; Marcilla, Antonio; Shekari, Faezeh; Shen, Tang Long; Torrecilhas, Ana Claudia; Yan, Xiaomei; Yang, Fuquan; Yin, Hang; Xiao, Yu; Zhao, Zezhou; Zou, Xue; Wang, Qian; Zheng, Lei (2020)The utilization of extracellular vesicles (EVs) in clinical theranostics has rapidly advanced in the past decade. In November 2018, the International Society for Extracellular Vesicles (ISEV) held a workshop on “EVs in ... -
Generation and Characterisation of Neratinib-resistant Breast Cancer Cell Line Variants.
O'Driscoll, Lorraine (2012) -
Global analysis of serum microRNAs as potential biomarkers for lung adenocarcinoma.
O'Driscoll, Lorraine; O'Byrne, Ken; Gately, Kathy (2013) -
Human bone marrow stem/stromal cell osteogenesis is regulated via mechanically activated osteocyte-derived extracellular vesicles
O'Driscoll, Lorraine; Hoey, David (2020)Bone formation or regeneration requires the recruitment, proliferation, and osteogenic differentiation of stem/stromal progenitor cells. A potent stimulus driving this process is mechanical loading. Osteocytes are ... -
Identification of predictive biomarkers for dasatinib treatment of metastatic melanoma.
O'Driscoll, Lorraine (2011) -
Inhibiting extracellular vesicles formation and release: a review of EV inhibitors.
O'Driscoll, Lorraine; Catalano, Mariadelva (2019)It is now becoming well established that vesicles are released from a broad range of cell types and are involved in cell-to-cell communication, both in physiological and pathological conditions. Once outside the cell, these ... -
Isosteviol has beneficial effects on palmitate-induced cell dysfunction and gene expression.
O'Driscoll, Lorraine (2012)BACKGROUND: Long-term exposure to high levels of fatty acids impairs insulin secretion and exaggerates glucagon secretion. The aim of this study was to explore if the antihyperglycemic agent, Isosteviol (ISV), is able ... -
MAGE-D4B is a novel marker of poor prognosis and potential therapeutic target involved in breast cancer tumorigenesis.
O'Driscoll, Lorraine (2012) -
Melanoma-associated antigen family protein-D4: clinical significance and functional relevance in breast cancer
O'Driscoll, Lorraine (2010)Melanoma-associated antigen (MAGE) family genes are broadly expressed during development and are involved in the regulation of cell survival, cell cycle progression and apoptosis. MAGE family proteins are generally described ... -
Mesenchymal Stem Cell Derived Extracellular Vesicles for Tissue Engineering and Regenerative Medicine Applications
O'Driscoll, Lorraine (2020)Mesenchymal stem cells (MSCs) are being extensively investigated for their potential in tissue engineering and regenerative medicine. However, recent evidence suggests that the beneficial effects of MSCs may be manifest ... -
Metabolic syndrome: a closer look at the growing epidemic and its associated pathologies
O'Driscoll, Lorraine (2015)Obesity is reaching epidemic proportions with recent worldwide figures estimated at 1.4 billion and rising year-on-year. Obesity affects all socioeconomic backgrounds and ethnicities and is a pre-requisite for metabolic ... -
A method of separating extracellular vesicles from blood shows potential clinical translation, and reveals extracellular vesicle cargo gremlin-1 as a diagnostic biomarker
O'Driscoll, Lorraine (2022)Extracellular vesicles (EVs) have potential as minimally invasive biomarkers. However, the methods most commonly used for EV retrieval rely on ultracentrifugation, are time-consuming, and unrealistic to translate to ... -
MicroRNA Profiling of Exosomes
O'Driscoll, Lorraine (Springer, 2017) -
Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines
O'Driscoll, Lorraine; Théry, Clotilde; Witwer, Kenneth W.; Aikawa, Elena; Alcarez, Maria Jose; Anderson, Johnathon D.; Andriantsitohaina, Ramaroson; Antoniou, Anna; Arab, Tanina; Archer, Fabienne; Atkin-Smith, Georgia K.; Ayre, D. Craig; Bach, Jean-Marie; Bachurski, Daniel; Baharvand, Hossein; Balaj, Leonora; Baldacchino, Shawn; Bauer, Natalie N.; Baxter, Amy A.; Bebawy, Mary; Beckham, Carla; Bedina Zavec, Apolonija; Benmoussa, Abderrahim; Berardi, Anna C.; Bergese, Paolo; Bielska, Ewa; Blenkiron, Cherie; Bobis-Wozowicz, Sylwia; Boilard, Eric; Boireau, Wilfrid (2019)The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of ...