Browsing by Author "GEOGHEGAN, JOAN"
Now showing items 21-30 of 30
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Role of surface protein SasG in biofilm formation by Staphylococcus aureus.
GEOGHEGAN, JOAN; FOSTER, TIMOTHY (2010) -
A short sequence within subdomain N1 of region A of the Staphylococcus aureus MSCRAMM clumping factor A is required for export and surface display.
GEOGHEGAN, JOAN; FOSTER, TIMOTHY (2014) -
Staphylococcus aureus and Atopic Dermatitis: A Complex and Evolving Relationship
GEOGHEGAN, JOAN; FOSTER, TIMOTHY (2017)Staphylococcus aureus is frequently isolated from the skin of atopic dermatitis (AD) patients during flares. The normal microbiota is disrupted and the diversity of the microorganisms on the skin is reduced. Many species ... -
The Staphylococcus aureus Cell Wall-Anchored Protein Clumping Factor A Is an Important T Cell Antigen.
GEOGHEGAN, JOAN; MCLOUGHLIN, RACHEL; LALOR, STEPHEN (2017) -
Staphylococcus aureus Fibronectin-Binding Protein A Mediates Cell-Cell Adhesion through Low-Affinity Homophilic Bonds.
GEOGHEGAN, JOAN; FOSTER, TIMOTHY (2015)Staphylococcus aureus is an important opportunistic pathogen which is a leading cause of biofilm-associated infections on indwelling medical devices. The cell surface-located fibronectin-binding protein A (FnBPA) plays an ... -
Staphylococcus aureus surface protein SdrE binds complement regulator factor H as an immune evasion tactic.
FOSTER, TIMOTHY JAMES; GEOGHEGAN, JOAN (2012)Similar to other highly successful invasive bacterial pathogens, Staphylococcus aureus recruits the complement regulatory protein factor H (fH) to its surface to inhibit the alternative pathway of complement. Here, we ... -
Staphylokinase Control of Staphylococcus aureus Biofilm Formation and Detachment Through Host Plasminogen Activation.
GEOGHEGAN, JOAN; FOSTER, TIMOTHY (2015)Staphylococcus aureus biofilms, a leading cause of persistent infections, are highly resistant to immune defenses and antimicrobial therapies. In the present study, we investigated the contribution of fibrin and staphylokinase ... -
Subdomains N2N3 of Fibronectin Binding Protein A Mediate Staphylococcus aureus Biofilm Formation and Adherence to Fibrinogen Using Distinct Mechanisms.
GEOGHEGAN, JOAN; FOSTER, TIMOTHY (2013)Health care-associated methicillin-resistant Staphylococcus aureus (HA-MRSA) forms biofilm in vitro that is dependent on the surface-located fibronectin binding proteins A and B (FnBPA, FnBPB). Here we provide new insights ... -
Targeted nasal vaccination provides antibody independent protection against Staphylococcus aureus.
MCLOUGHLIN, RACHEL; LAVELLE, EDWARD; GEOGHEGAN, JOAN; FOSTER, TIMOTHY (2014)Despite showing promise in preclinical models, anti–Staphylococcus aureus vaccines have failed in clinical trials. To date, approaches have focused on neutralizing/opsonizing antibodies; however, vaccines exclusively ... -
Zinc-dependent mechanical properties of Staphylococcus aureus biofilm-forming surface protein SasG
GEOGHEGAN, JOAN; FOSTER, TIMOTHY (2016)Staphylococcus aureus surface protein SasG promotes cell-cell adhesion during the accumulation phase of biofilm formation, but the molecular basis of this interaction remains poorly understood. Here, we unravel the mechanical ...