Browsing by Author "MORRIS, DEREK"
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CNV analysis in a large schizophrenia sample implicates deletions at 16p12.1 and SLC1A1 and duplications at 1p36.33 and CGNL1.
CORVIN, AIDEN; MORRIS, DEREK; GILL, MICHAEL (2014) -
Common variant at 16p11.2 conferring risk of psychosis
MORRIS, DEREK; GILL, MICHAEL (2012)Epidemiological and genetic data support the notion that schizophrenia and bipolar disorder share genetic risk factors. In our previous genome-wide association study, meta-analysis and follow-up (totaling as many as 18?206 ... -
Delineating the genetic heterogeneity of ALS using targeted high-throughput sequencing
MORRIS, DEREK; MCLAUGHLIN, RUSSELL (2013) -
Delineating the genetic heterogeneity of ALS using targeted high-throughput sequencing.
HARDIMAN, ORLA; CORVIN, AIDEN; MORRIS, DEREK; MCLAUGHLIN, RUSSELL; KENNY, ELAINE (2013) -
Development of Strategies for SNP Detection in RNA-Seq Data: Application to Lymphoblastoid Cell Lines and Evaluation Using 1000 Genomes Data.
MORRIS, DEREK; ANNEY, RICHARD JAMES LEON; CORVIN, AIDEN PETER; GILL, MICHAEL (2013)Next-generation RNA sequencing (RNA-seq) maps and analyzes transcriptomes and generates data on sequence variation in expressed genes. There are few reported studies on analysis strategies to maximize the yield of quality ... -
DNA methylation of the serotonin transporter gene in peripheral cells and stress-related changes in hippocampal volume: A study in depressed patients and healthy controls
FRODL, THOMAS; GILL, MICHAEL; MORRIS, DEREK; MEANEY, JAMES; MEANEY, JAMES; FRODL, THOMAS; MORRIS, DEREK; GILL, MICHAEL (2015)Serotonin plays an important role in the etiology of depression. Serotonin is also crucial for brain development. For instance, animal studies have demonstrated that early disruptions in the serotonin system affect brain ... -
Duplications of the neuropeptide receptor gene VIPR2 confer significant risk for schizophrenia.
MORRIS, DEREK; CORVIN, AIDEN; GILL, MICHAEL (2011)Rare copy number variants (CNVs) play a prominent role in the etiology of schizophrenia and other neuropsychiatric disorders 1 . Substantial risk for schizophrenia is conferred by large (>500 kb) CNVs at several loci, ... -
Early Visual Processing Deficits in Dysbindin-Associated Schizophrenia
ROBERTSON, IAN; GILL, MICHAEL; MORRIS, DEREK; GARAVAN, HUGH; CORVIN, AIDEN; FOXE, JOHN (2008)Background: Variation at the dysbindin gene (DTNBP1) has been associated with increased risk for schizophrenia in numerous independent samples and recently with deficits in general and domain-specific cognitive processing. ... -
Effect of genetic variant in BICCI on functional and structural brain changes in depression
GILL, MICHAEL; DONOHOE, GARY; FAGAN, ANDREW; MORRIS, DEREK; FRODL, THOMAS (2012) -
The effect of the neurogranin schizophrenia risk variant rs12807809 on brain structure and function.
MORRIS, DEREK; MC GRATH, JANE; ROBERTSON, IAN H; NEWELL, FIONA; O'DOHERTY, JOHN PHILIP; GILL, MICHAEL; TROPEA, DANIELA; DONOHOE, GARY (JAMES); CORVIN, AIDEN PETER; GARAVAN, HUGH PATRICK; BOKDE, ARUN LAWRENCE WARREN (2012)A single nucleotide polymorphism rs12807809 located upstream of the neurogranin (NRGN) gene has been identified as a risk variant for schizophrenia in recent genome-wide association studies. To date, there has been little ... -
Effects of a novel schizophrenia risk variant rs7914558 at CNNM2 on brain structure and attributional style.
MORRIS, DEREK; DONOHOE, GARY; HARGREAVES, APRIL; GILL, MICHAEL; FAHEY, CIARA; CORVIN, AIDEN; TROPEA, DANIELA (2014)BACKGROUND: A single nucleotide polymorphism (rs7914558) within the cyclin M2 (CNNM2) gene was recently identified as a common risk variant for schizophrenia. The mechanism by which CNNM2 confers risk is unknown. AIMS: To ... -
Effects of MIR137 on fronto-amygdala functional connectivity.
FAHEY, CIARA; MORRIS, DEREK; KELLY, SINEAD; GILL, MICHAEL; DONOHOE, GARY; REILLY, RICHARD; CORVIN, AIDEN (2014)MIR137 is implicated in brain development and encodes a microRNA that regulates neuronal maturation and adult neurogenesis. Recently, a common genetic variant within MIR137 showed genome wide evidence of association with ... -
Effects of ZNF804A on auditory P300 response in schizophrenia.
GILL, MICHAEL; CORVIN, AIDEN; DONOHOE, GARY; MORRIS, DEREK; TROPEA, DANIELA (2014) -
The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data
MORRIS, DEREK; DONOHOE, GARY (2014) -
Evaluation of a Susceptibility Gene for Schizophrenia: Genotype Based Meta-Analysis of RGS4 Polymorphisms from Thirteen Independent Samples
MORRIS, DEREK; CORVIN, AIDEN; GILL, MICHAEL (2006) -
Evidence that duplications of 22q11.2 protect against schizophrenia.
GILL, MICHAEL; CORVIN, AIDEN; MORRIS, DEREK (2014)A number of large, rare copy number variants (CNVs) are deleterious for neurodevelopmental disorders, but large, rare, protective CNVs have not been reported for such phenotypes. Here we show in a CNV analysis of 47 005 ... -
Excess of rare novel loss-of-function variants in synaptic genes in schizophrenia and autism spectrum disorders.
CORVIN, AIDEN; HERON, ELIZABETH; GILL, MICHAEL; DONOHOE, GARY; ANNEY, RICHARD; GALLAGHER, LOUISE; MORRIS, DEREK; TROPEA, DANIELA; KENNY, ELAINE (2014) -
Expression of glucocorticoid inducible genes is associated with reductions in cornu ammonis and dentate gyrus volumes in patients with major depressive disorder.
GILL, MICHAEL; HARKIN, ANDREW; MORRIS, DEREK; O'KEANE, VERONICA (2014) -
Fine mapping of ZNF804A and genomime-wide significant evidence for it's involvement in Schizophrenia and bipolar disorder.
GILL, MICHAEL; CORVIN, AIDEN; MORRIS, DEREK; QUINN, EMMA (2011)A recent genome-wide association study (GWAS) reported evidence for association between rs1344706 within ZNF804A (encoding zinc-finger protein 804A) and schizophrenia (P=1.61 × 10(-7)), and stronger evidence when the ...