Browsing by Author "MORRIS, DEREK"
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Functional gene group analysis identifies synaptic gene groups as risk factor for schizophrenia.
GILL, MICHAEL; MORRIS, DEREK; KENNY, ELAINE; CORVIN, AIDEN (2012)Schizophrenia is a highly heritable disorder with a polygenic pattern of inheritance and a population prevalence of _1%. Previous studies have implicated synaptic dysfunction in schizophrenia. We tested the accumulated ... -
Further evidence of alerted default network connectivity and association with theory of mind ability in schizophrenia
GILL, MICHAEL; DONOHOE, GARY; CORVIN, AIDEN; MORRIS, DEREK; FRODL, THOMAS (2016)Background: Resting-state functional magnetic resonance imaging (rs-fMRI) has repeatedly shown evidence of altered functional connectivity of large-scale networks in schizophrenia. The relationship between these connectivity ... -
Genetic Classification of Populations using Supervised Learning.
GILL, MICHAEL; MORRIS, DEREK; HERON, ELIZABETH; CORVIN, AIDEN; PINTO, CARLOS (2011)There are many instances in genetics in which we wish to determine whether two candidate populations are distinguishable on the basis of their genetic structure. Examples include populations which are geographically ... -
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
MORRIS, DEREK; CORVIN, AIDEN; GILL, MICHAEL (2013) -
Genome-wide association study identifies five new schizophrenia loci.
MORRIS, DEREK; CORVIN, AIDEN PETER; GILL, MICHAEL; DONOHOE, GARY (JAMES) (2011)We examined the role of common genetic variation in schizophrenia in a genome-wide association study of substantial size: a stage 1 discovery sample of 21,856 individuals of European ancestry and a stage 2 replication ... -
Genome-wide association study implicates HLA-C*01:02 as a risk factor at the major histocompatibility complex locus in schizophrenia.
MORRIS, DEREK; DONOHOE, GARY (JAMES); GILL, MICHAEL; CORVIN, AIDEN PETER (2012)Background? We performed a genome-wide association study (GWAS) to identify common risk variants for schizophrenia. Methods? The discovery scan included 1606 patients and 1794 controls from Ireland, using 6,212,339 ... -
Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms.
IRVINE, ALAN; CORVIN, AIDEN; MORRIS, DEREK (2015)Atopic dermatitis and psoriasis are the two most common immune-mediated inflammatory disorders affecting the skin. Genome-wide studies demonstrate a high degree of genetic overlap, but these diseases have mutually exclusive ... -
Geonome-wide linkage analysis of 972 bipolar pedigrees using single-nucleotide polymorphisms
MORRIS, DEREK; GILL, MICHAEL (2011)Because of the high costs associated with ascertainment of families, most linkage studies of Bipolar I disorder (BPI) have used relatively small samples. Moreover, the genetic information content reported in most studies ... -
Global endometrial transcriptomic profiling: transient immune activation precedes tissue proliferation and repair in healthy beef cows.
MORRIS, DEREK; O'FARRELLY, CLIONA; NARCIANDI MARTIN, FERNANDO; KENNY, ELAINE (2012) -
GWA study data mining and independent replication identify cardiomyopathy-associated 5 (CMYA5) as a risk gene for schizophrenia.
GILL, MICHAEL; CORVIN, AIDEN PETER; MORRIS, DEREK (Nature, 2010)We conducted data-mining analyses using the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) and molecular genetics of schizophrenia genome-wide association study supported by the genetic association ... -
Identification of common variants associated with human hippocampal and intracranial volumes.
CORVIN, AIDEN; DONOHOE, GARY; MORRIS, DEREK; GILL, MICHAEL; LOPEZ, LORNA (2012) -
Identification of mechanosensitive genes during skeletal development: Alteration of genes associated with cytoskeletal rearrangement and cell signalling pathways
MORRIS, DEREK; KELLY, DANIEL; Prendergast, Patrick; ROLFE, REBECCA (2014)Background Mechanical stimulation is necessary for regulating correct formation of the skeleton. Here we test the hypothesis that mechanical stimulation of the embryonic skeletal system impacts expression levels of genes ... -
Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions.
CORVIN, AIDEN PETER; GILL, MICHAEL; MORRIS, DEREK (2009)Translating a set of disease regions into insight about pathogenic mechanisms requires not only the ability to identify the key disease genes within them, but also the biological relationships among those key genes. Here ... -
Implication of a Rare Deletion at Distal 16p11.2 in Schizophrenia.
MORRIS, DEREK; CORVIN, AIDEN; GILL, MICHAEL (2013) -
Influence of NOS1 on verbal intelligence and working memory in both patients with schizophrenia and healthy control subjects.
DONOHOE, GARY; MORRIS, DEREK; CORVIN, AIDEN; O'DONOGHUE, THERESE; GILL, MICHAEL; QUINN, EMMA (2009)Background: Human and animal studies have implicated the gene NOS1 in both cognition and schizophrenia susceptibility. Objectives: To investigate whether a potential schizophrenia risk SNP (rs6490121) identified in a recent ... -
An inherited duplication at the gene p21 Protein-Activated Kinase 7 (PAK7) is a risk factor for psychosis.
GILL, MICHAEL; CORVIN, AIDEN; MORRIS, DEREK; DONOHOE, GARY; TROPEA, DANIELA; KENNY, ELAINE (2014) -
Investigation of the genetic association between quantitative measures of psychosis and schizophrenia: a polygenic risk score analysis.
MORRIS, DEREK; DONOHOE, GARY (JAMES); GILL, MICHAEL; CORVIN, AIDEN PETER (2012)The presence of subclinical levels of psychosis in the general population may imply that schizophrenia is the extreme expression of more or less continuously distributed traits in the population. In a previous study, we ... -
The miR-137 schizophrenia susceptibility variant rs1625579 does not predict variability in brain volume in a sample of schizophrenic patients and healthy individuals.
GILL, MICHAEL; DONOHOE, GARY; MORRIS, DEREK; CORVIN, AIDEN (2014)