Browsing by Author "MORRIS, DEREK"
Now showing items 49-68 of 68
-
Molecular genetic evidence for overlap between general cognitive ability and risk for schizophrenia: a report from the Cognitive Genomics consorTium (COGENT).
GILL, MICHAEL; CORVIN, AIDEN; DONOHOE, GARY; MORRIS, DEREK (2014)It has long been recognized that generalized deficits in cognitive ability represent a core component of schizophrenia (SCZ), evident before full illness onset and independent of medication. The possibility of genetic ... -
Multiplex Target Enrichment Using DNA Indexing for Ultra-High Throughput SNP Detection.
KENNY, ELAINE; GILKS, WILLIM PETER; CORMICAN, PAUL; MORRIS, DEREK; CORVIN, AIDEN; GILL, MICHAEL; PINTO, CARLOS (2011)Screening large numbers of target regions in multiple DNA samples for sequence variation is an important application of next-generation sequencing but an efficient method to enrich the samples in parallel has yet to be ... -
Mutation of Semaphorin-6A Disrupts Limbic and Cortical Connectivity and Models Neurodevelopmental Psychopathology
GILL, MICHAEL; MORRIS, DEREK; CORVIN, AIDEN; MITCHELL, KEVIN (2011)Psychiatric disorders such as schizophrenia and autism are characterised by cellular disorganisation and dysconnectivity across the brain and can be caused by mutations in genes that control neurodevelopmental processes. ... -
No evidence that runs of homozygosity are associated with schizophrenia in an Irish genome-wide association dataset
HERON, ELIZABETH; DONOHOE, GARY; MORRIS, DEREK; CORVIN, AIDEN; GILL, MICHAEL (2014)Runs of homozygosity (ROH), regions of the genome containing many consecutive homozygous SNPs, may represent two copies of a haplotype inherited from a common ancestor. A rare variant on this haplotype could thus be present ... -
Non-random error in genotype calling procedures: Implications for family-based and case-control genome-wide association studies
MORRIS, DEREK; GILL, MICHAEL (2008) -
A NOS1 variant implicated in cognitive performance influences evoked neural responses during a hight density EEG study of early visual perception.
GILL, MICHAEL; CORVIN, AIDEN; MORRIS, DEREK; DONOHOE, GARY; FAHEY, CIARA (Wiley Open Access, 2012)Background: The nitric oxide synthasase‐1 gene (NOS1) has been implicated in mental disorders including schizophrenia and variation in cognition. The NOS1 variant rs6490121 identified in a genome wide association study of ... -
The NOS1 variant rs6490121 is associated with variation in prefrontal function and gray matter density in healthy individuals
FRODL, THOMAS; DONOHOE, GARY (JAMES); GILL, MICHAEL; CORVIN, AIDEN PETER; NEWELL, FIONA; ROSE, EMMA; FAHEY, CIARA; GARAVAN, HUGH PATRICK; BOKDE, ARUN LAWRENCE WARREN; O'DOHERTY, JOHN PHILIP; MC GRATH, JANE; KELLY, SINEAD; ROBERTSON, IAN H; MORRIS, DEREK (Elsevier, 2012)A common polymorphism within the nitric oxide sythanse-1 (NOS1) gene (rs6490121), initially identified as risk variant for schizophrenia, has been associated with variation in working memory and IQ. Here we investigated ... -
De novo mutations in schizophrenia implicate chromatin remodeling and support a genetic overlap with autism and intellectual disability
GILL, MICHAEL; MORRIS, DEREK; CORVIN, AIDEN; DONOHOE, GARY; KELLEHER, DERMOT (2014) -
The one and the many: effects of the cell adhesion molecule pathway on neuropsychological function in psychosis
HARGREAVES, APRIL; GILL, MICHAEL; MORRIS, DEREK; ANNEY, RICHARD; CORVIN, AIDEN; DONOHOE, GARY (2013) -
Population structure and genome-wide patters of variation in Ireland and Britain.
GILL, MICHAEL; CORVIN, AIDEN; MORRIS, DEREK (2010) -
The psychosis susceptibility gene ZNF804A: associations, functions, and phenotypes.
MORRIS, DEREK; DONOHOE, GARY; CORVIN, AIDEN (2010) -
Rare chromosomal deletions and duplications increase risk of schizophrenia.
CORVIN, AIDEN PETER; MORRIS, DEREK (2008)Schizophrenia is a severe mental disorder marked by hallucinations, delusions, cognitive deficits and apathy, with a heritability estimated at 73-90% (ref. 1). Inheritance patterns are complex, and the number and type of ... -
Runs of homozygosity implicate autozygosity as a schizophrenia risk factor.
MORRIS, DEREK; GILL, MICHAEL; CORVIN, AIDEN PETER (2012)Autozygosity occurs when two chromosomal segments that are identical from a common ancestor are inherited from each parent. This occurs at high rates in the offspring of mates who are closely related (inbreeding), but ... -
The SNP ratio test: pathway analysis of genome-wide association datasets
MORRIS, DEREK; HERON, ELIZABETH ANN; CORVIN, AIDEN PETER; GILL, MICHAEL; O'Dushlaine, Colm; Kenny, Elaine; Segurado, Ricardo (2009)Summary: We present a tool that assesses the enrichment of significant associations from genome-wide association studies (GWAS) in a pathway context. The SNP ratio test (SRT) compares the proportion of significant to ... -
Social dysfunction in schizophrenia: An investigation of the GAF scale's sensitivity to deficits in social cognition.
MORRIS, DEREK; HARGREAVES, APRIL; CORVIN, AIDEN PETER; GILL, MICHAEL; ROBERTSON, DEIRDRE; DONOHOE, GARY (JAMES) (2013)BACKGROUND: Schizophrenia is accompanied by significant impairment in psychosocial functioning, which is only partially explained by clinical symptom severity. Recently, these impairments have been strongly associated ... -
Variation in DNA repair genes XRCC3, XRCC4, XRCC5 and susceptibility to myeloma.
MORRIS, DEREK (2007) -
ZNF804A risk allele is associated with relatively intact gray matter volume in patients with schizophrenia
CORVIN, AIDEN PETER; ROSE, EMMA; DONOHOE, GARY (JAMES); FRODL, THOMAS; MORRIS, DEREK; GILL, MICHAEL (Elsevier, 2010)ZNF804A rs1344706 is the first genetic risk variant to achieve genome wide significance for psychosis. Following earlier evidence that patients carrying the ZNF804A risk allele had relatively spared memory function compared ...