Browsing RSS Feeds by Subject "T-cell"

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  • Akt and STAT5 mediate naïve human CD4+ T-cell early metabolic response to TCR stimulation 

    Finlay, David; Jones, Nicholas; Vincent, Emma E.; Cronin, James G.; Panetti, Silvia; Chambers, Megan; Holm, Sean R.; Owens, Sian E.; Francis, Nigel J.; Thornton, Catherine A. (2019)
    Metabolic pathways that regulate T-cell function show promise as therapeutic targets in diverse diseases. Here, we show that at rest cultured human effector memory and central memory CD4+ T-cells have elevated levels of ...

  • Phosphorylation of Rab5a protein by protein kinase Cϵ Is crucial for T-cell migration 

    Long, Aideen; Ong, Seow Theng; Freeley, Michael; Skubis-Zegladło, Joanna; Hussain Urf Turabe Fazil, Mobashar; Kelleher, Dermot; Fresser, Friedrich; Baier, Gottfried; Verma, Navin K. (2014)
    Rab GTPases control membrane traffic and receptor-mediated endocytosis. Within this context, Rab5a plays an important role in the spatial regulation of intracellular transport and signal transduction processes. Here, we ...