Iron Status and Helicobacter pylori Infection in Symptomatic Children: An International Multi-Centered Study
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2013Access:
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Queiroz, D.M.M., Harris, P.R., Sanderson, I.R., Windle, H.J., Walker, M.M., Rocha, A.M.C., Rocha, G.A., (...), Crabtree, J.E, Iron Status and Helicobacter pylori Infection in Symptomatic Children: An International Multi-Centered Study, PLoS ONE, 8, 7, 2013, art. no. e68833Download Item:
Abstract:
Objective:
Iron deficiency (ID) and iron deficiency anaemia (IDA) are global major public health problems, particularly in
developing countries. Whilst an association between
H. pylori
infection and ID/IDA has been proposed in the literature,
currently there is no consensus. We studied the effects of
H. pylori
infection on ID/IDA in a cohort of children undergoing
upper gastrointestinal endoscopy for upper abdominal pain in two developing and one developed country.
Methods:
In total 311 children (mean age 10.7
6
3.2 years) from Latin America - Belo Horizonte/Brazil (n = 125), Santiago/
Chile (n = 105) - and London/UK (n = 81), were studied. Gastric and duodenal biopsies were obtained for evaluation of
histology and
H. pylori
status and blood samples for parameters of ID/IDA.
Results:
The prevalence of
H. pylori
infection was 27.7% being significantly higher (p
,
0.001) in Latin America (35%) than in
UK (7%). Multiple linear regression models revealed
H. pylori
infection as a significant predictor of low ferritin and
haemoglobin concentrations in children from Latin-America. A negative correlation was observed between MCV (r =
2
0.26;
p = 0.01) and MCH (r =
2
0.27; p = 0.01) values and the degree of antral chronic inflammation, and between MCH and the
degree of corpus chronic (r =
2
0.29, p = 0.008) and active (r =
2
0.27, p = 0.002) inflammation.
Conclusions:
This study demonstrates that
H. pylori
infection in children influences the serum ferritin and haemoglobin
concentrations, markers of early depletion of iron stores and anaemia respectively
Author's Homepage:
http://people.tcd.ie/kellehdphttp://people.tcd.ie/hjwindle
Description:
PUBLISHED
Author: WINDLE, HENRY; KELLEHER, DERMOT P
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PLoS ONE;8;
7;
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