Browsing Administrative Staff Authors (Scholarly Publications) by Sponsor "Health Research Board (HRB)"
Now showing items 1-11 of 11
-
Analysis of dynamic tyrosine phosphoproteome in LFA-1 triggered migrating T-cells.
(2011)The ordered, directional migration of T-lymphocytes is a key process during immune surveillance and response. This requires cell adhesion to the high endothelial venules or to the extracellular matrix by a series of surface ... -
Bile acid toxicity structure activity relationships: Correlations between cell viability and lipophilicity in a panel of new and known bile acids using an esophageal cell line (HET-1A)
(2010)The molecular mechanisms and interactions underlying bile acid cytotoxicity are important to understand for intestinal and hepatic disease treatment and prevention and the design of bile acid-based therapeutics. Bile acid ... -
Characterising cytokine gene expression signatures in patients with severe sepsis
(2013)Introduction. Severe sepsis in humans may be related to an underlying profound immune suppressive state. We investigated the link between gene expression of immune regulatory cytokines and the range of illness severity in ... -
Crosslinking and mechanical properties significantly influence cell attachment, proliferation, and migration within collagen glycosaminoglycan scaffolds.
(2011)Crosslinking and the resultant changes in mechanical properties have been shown to influence cellular activity within collagen biomaterials. With this in mind, we sought to determine the effects of crosslinking on both the ... -
A framework for assessing health system resilience in an economic crisis: Ireland as a test case
(2013)BACKGROUND: The financial crisis that hit the global economy in 2007 was unprecedented in the post war era. In general the crisis has created a difficult environment for health systems globally. The purpose of this paper ... -
Molecular footprints reveal the impact of the protective HLA-A*03 allele in hepatitis C virus infection.
(2011)Background and aims: CD8 T cells are central to the control of hepatitis C virus (HCV) although the key features of a successful CD8 T cell response remain to be defined. In a cohort of Irish women infected by a single ... -
The prevalence of alpha-1 antitrypsin deficiency in Ireland
(2011)Background: Alpha-1 antitrypsin deficiency (AATD) results from mutations in the SERPINA1 gene and classically presents with early-onset emphysema and liver disease. The most common mutation presenting with clinical evidence ... -
Propofol allows precise quantitative arterial spin labelling functional magnetic resonance imaging in the rat
(2010)Functional magnetic resonance imaging (fMRI) techniques highlight cerebral vascular responses which are coupled to changes in neural activation. However, two major difficulties arise when employing these techniques in ... -
Site specific increase in heterogeneity of trabecular bone tissue mineral during oestrogen deficiency.
(2011)Although osteoporosis reduces overall bone mass causing bone fragility, recent studies report that the remaining bone tissue is significantly stiffer. Preliminary studies indicate that alterations in bone tissue mineral ... -
Staphylococcus aureus Protein A Binds to Osteoblasts and Triggers Signals That Weaken Bone in Osteomyelitis.
(2011)Osteomyelitis is a debilitating infectious disease of the bone. It is predominantly caused by S. aureus and is associated with significant morbidity and mortality. It is characterised by weakened bones associated with ...