Browsing Administrative Staff Authors (Scholarly Publications) by Author "COSTELLO, DEREK"
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Brain deletion of insulin receptor substrate 2 disrupts hippocampal synaptic plasticity and metaplasticity
COSTELLO, DEREK (2012)Objective: Diabetes mellitus is associated with cognitive deficits and an increased risk of dementia, particularly in the elderly. These deficits and the corresponding neurophysiological structural and functional alterations ... -
IL-1alpha and HMGB1 mediate hippocampal dysfunction in SIGIRR-deficient mice
LYNCH, MARINA ANNETTA; COSTELLO, DEREK (2011)Single-Ig-interleukin-1 related receptor (SIGIRR) is a member of the interleukin (IL)-1/Toll-like receptor (TLR) family. It negatively regulates inflammation, rendering SIGIRR-/- mice more susceptible to inflammatory ...