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dc.contributor.authorGrimes, Tamasineen
dc.contributor.authorWiddowson, Matten
dc.date.accessioned2020-01-08T15:25:31Z
dc.date.available2020-01-08T15:25:31Z
dc.date.issued2020en
dc.date.submitted2020en
dc.identifier.citationSmeaton T., McElwaine P., C ullen J, Santos - Martinez M. J.,D easy E., Widdowson M., Grimes T . C ., A prospective observational pilot study of adverse drug reactions contributing to hospitalisation in a cohort of middle-aged adults aged 45- 64 years., Drugs & Therapy Perspectives, 2020en
dc.identifier.otherYen
dc.identifier.urihttps://link.springer.com/content/pdf/10.1007/s40267-019-00700-1.pdf
dc.identifier.urihttp://hdl.handle.net/2262/91265
dc.descriptionPUBLISHEDen
dc.description.abstractPurpose: Determine the prevalence, severity and preventability of adverse drug reactions (ADRs), ADRs causing or contributing to hospitalisation (cADRs) and preventable ADRs (pADRs) in middle-aged patients aged 45-64 years presenting acutely to hospital. Methods: Prospective observational pilot study. The sampling frame was middle-aged patients in the Acute Medical Unit of an Irish university teaching hospital. 100 patients using ≥3 medicines were screened for ADRs present at hospitalisation. Potential ADRs were assessed for causality, preventability, severity and relationship to hospitalisation using validated tools and clinician assessment. The associations between ADRs and potentially inappropriate prescribing (PIP) and polypharmacy (≥5 medicines) were investigated using the Pearson’s chi-squared test. Multi-variate logistic regression analyses examined association between ADRs and sex, age, polypharmacy, co-morbidity and PIP. Results: Twenty-one of 100 patients experienced 23 ADRs. Prevalence of cADR and pADR was 14% and 11% of patients respectively. Over half of ADRs identified (n=14) were sufficiently severe to prompt presentation to hospital for urgent medical review. PIP was associated with occurrence of any ADR (adjusted odds ratio 3.49, 95% CI 1.22-9.93), but not with cADR. Excessive polypharmacy (≥10 medicines) (χ2=5.73, p=0.02), but not polypharmacy, was associated with any ADR occurrence. Conclusions: One in five patients had an ADR and experienced short-term morbidity as a result. For 11 patients, the experienced ADR was preventable. These findings illustrate that middle-aged patients are vulnerable to medicine-related harm. Additional research in larger studies is needed to more comprehensively describe ADR prevalence in middle-age as well as the risk factors for same.en
dc.language.isoenen
dc.relation.ispartofseriesDrugs & Therapy Perspectivesen
dc.rightsYen
dc.subjectMiddle ageen
dc.subjectAdverse drug reactionen
dc.subjectHospitalisationen
dc.subjectPolypharmacyen
dc.subjectPotentially inappropriate prescribingen
dc.titleA prospective observational pilot study of adverse drug reactions contributing to hospitalisation in a cohort of middle-aged adults aged 45- 64 years.en
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/tagrimesen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/widdowsmen
dc.identifier.rssinternalid208718en
dc.identifier.doihttp://dx.doi.org/10.1007/s40267-019-00700-1en
dc.rights.ecaccessrightsopenAccess
dc.subject.TCDThemeAgeingen
dc.subject.TCDThemeInclusive Societyen
dc.subject.TCDTagADVERSE DRUG REACTIONSen
dc.subject.TCDTagMedication safetyen
dc.subject.TCDTagPatient safetyen
dc.identifier.orcid_id0000-0002-7154-3243en
dc.status.accessibleNen


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