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dc.contributor.authorMCLOUGHLIN, RACHELen
dc.contributor.authorLAVELLE, EDWARDen
dc.contributor.authorGEOGHEGAN, JOANen
dc.contributor.authorFOSTER, TIMOTHYen
dc.date.accessioned2014-12-01T11:11:42Z
dc.date.available2014-12-01T11:11:42Z
dc.date.issued2014en
dc.date.submitted2014en
dc.identifier.citationMisstear K, McNeela EA, Murphy AG, Geoghegan JA, O'Keeffe KM, Fox J, Chan K, Heuking S, Collin N, Foster TJ, McLoughlin RM, Lavelle EC, Targeted nasal vaccination provides antibody independent protection against Staphylococcus aureus., The Journal of infectious diseases, 209, 9, 2014, 1479-1484en
dc.identifier.issn0022-1899en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/72309
dc.descriptionPUBLISHEDen
dc.description.abstractDespite showing promise in preclinical models, anti–Staphylococcus aureus vaccines have failed in clinical trials. To date, approaches have focused on neutralizing/opsonizing antibodies; however, vaccines exclusively inducing cellular immunity have not been studied to formally test whether a cellular-only response can protect against infection. We demonstrate that nasal vaccination with targeted nanoparticles loaded with Staphylococcus aureus antigen protects against acute systemic S. aureus infection in the absence of any antigen-specific antibodies. These findings can help inform future developments in staphylococcal vaccine development and studies into the requirements for protective immunity against S. aureus.en
dc.format.extent1479-1484en
dc.language.isoenen
dc.relation.ispartofseriesThe Journal of infectious diseasesen
dc.relation.ispartofseries209en
dc.relation.ispartofseries9en
dc.rightsYen
dc.subjectnanoparticleen
dc.subjectadjuvanten
dc.subjectmucosalen
dc.subjectcellular immunityen
dc.subjectStaphylococcus aureusen
dc.subjectvaccineen
dc.titleTargeted nasal vaccination provides antibody independent protection against Staphylococcus aureus.en
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/geoghejoen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/lavelleeen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/mclougrmen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/tfosteren
dc.identifier.rssinternalid89833en
dc.identifier.doihttp://dx.doi.org/10.1093/infdis/jit636en
dc.rights.ecaccessrightsopenAccess
dc.subject.TCDThemeImmunology, Inflammation & Infectionen
dc.subject.TCDThemeNanoscience & Materialsen
dc.identifier.orcid_id0000-0002-3788-0668en


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