RSS 1.0Pharmacology & Therapeutics
Collections in this Academic/Research Unit
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Pharmacology & Therapeutics (Live Theses)
Pharmacology & Therapeutics (Live Theses) -
Pharmacology & Therapeutics (Scholarly Publications)
Pharmacology & Therapeutics (Scholarly Publications) -
Pharmacology & Therapeutics (Theses and Dissertations)
Pharmacology & Therapeutics (Theses and Dissertations)
Recent Submissions
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Inhibition of PP2A in a mono and co-culture model of hepatocelluar carcinoma : implications on the regulation of the matrix metalloproteinase system and the formation of the metastatic niche
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2016)Okadaic acid alteration in Hep3B cells Phosphoproteome: Cell proliferation was measured by MTT assay. Okadaic acid (OA; 40 nM) increased HepSB cells cell proliferation after 12, 24 and 48 h compared to untreated control ... -
The cost-effectiveness of Hepatitis C treatments in Ireland : a multi-technology assessment
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2016)Introduction Chronic Hepatitis C (HCV) is an important public health concern with an estimated 20,000 to 50,000 people infected in Ireland. Horizon scanning at the National Centre for Pharmacoeconomics in 2011 identified ... -
Patient-derived tau and amyloid-beta facilitate long-term depression in vivo: role of tumor necrosis factor alpha and the integrated stress response
(2024)Alzheimer’s disease is characterized by progressive cognitive decline in older individuals accompanied by the deposition of two pathognomonic proteins amyloid β (Aβ) and tau. It is well documented that synaptotoxic soluble ... -
The innate immunomodulatory effects of Aquamin in the context of the metabolic syndrome
(Trinity College Dublin. School of Medicine. Discipline of Pharmacology & Therapeutics, 2023)Metabolic disease is a combination of conditions that manifest together, elevating the risk for cardiovascular disease, type 2 diabetes and stroke. Inflammation is a major contributor in the pathophysiology of metabolic ... -
Health Technology Assessment of CD19 CAR T-Cell Therapies in the Irish Healthcare Setting.
(Trinity College Dublin. School of Medicine. Discipline of Pharmacology & Therapeutics, 2022)The aim of this research was to undertake health technology assessments of CD19 CAR T-cell therapies, tisagenlecleucel and axicabtagene ciloleucel. A bespoke cost-utility model was developed to examine the cost effectiveness ... -
Role of Protein Phosphatase 2A inhibition in modulation of VE-cadherin and Claudin-5 in human brain microvascular endothelial cells and the potential reversal by small molecule activators of PP2A (SMAPs)
(Trinity College Dublin. School of Medicine. Discipline of Pharmacology & Therapeutics, 2021)Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase which plays a key role in modulating signalling, metabolism and cell growth, and is implicated in various pathologies. There is conflicting evidence regarding ... -
Cost Effectiveness of PCSK9 Inhibitors for the Secondary Prevention of Cardiovascular Disease in Ireland: Considerations given to Population Heterogeneity
(Trinity College Dublin. School of Medicine. Discipline of Pharmacology & Therapeutics, 2020)The aim of this thesis was to evaluate the cost-effectiveness of PCSK9 inhibitors (alirocumab and evolocumab for the secondary prevention of CVD (cardiovascular disease) in Ireland. Also, to identify the subgroups of this ... -
Cost Effectiveness of Treatment Strategies for Skin Cancer in the Irish Healthcare Setting
(Trinity College Dublin. School of Medicine. Discipline of Pharmacology & Therapeutics, 2020)The incidence of both non-melanoma skin cancer (NMSC) and melanoma skin cancer are increasing in Ireland and are associated with significant healthcare costs. Cost-effectiveness analysis (CEA) can assist in resource ... -
Aß Facilitates LTD at Schaffer Collateral Synapses Preferentially in the Left Hippocampus
(2018)Promotion of long-term depression (LTD) mechanisms by synaptotoxic soluble oligomers of amyloid-β (Aß) has been proposed to underlie synaptic dysfunction in Alzheimer’s disease (AD). Previously, LTD was induced by relatively ... -
Physiological activation of mGlu5 receptors supports the ion channel function of NMDA receptors in hippocampal LTD induction in vivo
(2018)Synaptic long-term depression (LTD) is believed to underlie critical mnemonic processes in the adult hippocampus. The roles of the metabotropic and ionotropic actions of glutamate in the induction of synaptic LTD by ... -
Extracellular forms of A� and tau from iPSC models of Alzheimer's disease disrupt synaptic plasticity
(2018)The early stages of Alzheimer’s disease are associated with synaptic dysfunction prior to overt loss of neurons. To identify extracellular molecules that impair synaptic plasticity in the brain, we studied the secretomes ... -
Antibodies prevent the acute inhibition of long term potentiation by amyloid beta in the rat hippocampus
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2010)The present study investigated the mechanisms underlying the inhibition of long-term potentiation (LTP) of excitatory synaptic transmission by amyloid beta (Aβ) in the anaesthetized rat hippocampus. The role of soluble Aβ ... -
A study of the impact of highly active antiretroviral therapy on the pharmacoepidemiology and pharmacoeconomics of HIV infection
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2001)The HIV pandemic has resulted in the most intense and as yet unparalleled effort devoted to antimicrobial drug development ever to be initiated in the developed world. The intensive drug research and development, compressed ... -
Arterial pulse in health and disease
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2002)Arterial stiffness exerts a major influence on cardiac afterload and coronary perfusion. Indices of arterial stiffness have therefore been proposed as surrogate markers of cardiovascular risk and as a potential therapeutic ... -
Local modulation of pulmonary vascular function
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2000)The aim of the present study was to investigate the role of endothelial smooth muscle interaction in the local modulation of pulmonary vascular function. The main part of the work was carried out in isolated rings of porcine ... -
Adherence to antihypertensive medication in the United Arab Emirates : patient and doctor perspectives
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2003)Approximately half of the patients taking medication for hypertension have problems following the prescribed regime to the extent that they do not derive optimal clinical benefit. Prior to this study, there was little data ... -
Identifying early indicators of Emotional and Behavioural Difficulties in Irish children and testing the feasibility of an online parenting intervention for improving child mental health
(Trinity College Dublin. School of Medicine. Discipline of Pharmacology & Therapeutics, 2019)Background: Emotional and behavioural difficulties (EBDs) are the most common reason for referral of children and adolescents to mental health services. It is important, therefore, to assess the overall prevalence of EBD ... -
Pharmacoepidemiological studies of breast and colorectal cancer: The association between statins and cancer outcomes
(Trinity College Dublin. School of Medicine. Discipline of Pharmacology & Therapeutics, 2019)Breast and colorectal cancer are two of the most commonly diagnosed cancers in Ireland and worldwide, and a significant cause of cancer deaths. Statins, which are drugs that are commonly used in the prevention of ... -
Association of PP2A and VE-cadherin in a mono and co-culture with implications on brain microvascular permeability
(Trinity College Dublin. School of Medicine. Discipline of Pharmacology & Therapeutics, 2019)Introduction: Based on the knowledge that VE-cadherin is an integral component of the functioning endothelium in the blood brain barrier. Its transcellular abundance can be altered by post-translational modifications and ... -
The Pharmacokinetic Interaction between Ivacaftor and Ritonavir
(Trinity College Dublin. School of Medicine. Discipline of Pharmacology & Therapeutics, 2019)Ivacaftor is the first small molecule for the treatment of cystic fibrosis (CF) that directly targets the inherited defect in the cystic fibrosis transmembrane conductance regulator (CFTR). In phase III clinical trials ...
