RSS 1.0School of Genetics & Microbiology
Academic/Research Units within this Academic/Research Unit
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Biology Teaching Centre
Biology Teaching Centre -
Genetics
Genetics -
Microbiology
Microbiology
Recent Submissions
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Aspergillus fumigatus mitogen-activated protein kinase MpkA is involved in gliotoxin production and self-protection
(2024)Aspergillus fumigatus is a saprophytic fungus that can cause a variety of human diseases known as aspergillosis. Mycotoxin gliotoxin (GT) production is important for its virulence and must be tightly regulated to avoid ... -
The ophthalmic manifestations of neurological disease
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2024)The retina is responsible for visual processing by converting light signals into nerve impulses. It comprises both the central retina, termed the macula, and the peripheral retina. There are several subtypes of peripheral ... -
Characterisation of the floral transcriptome of Sinapis alba and analysis of PRC2 accessory proteins in Arabidopsis thaliana
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2024)Flower development has been studied in the model organism Arabidopsis thaliana for decades. Years of research into the development of the floral organs - carpels, stamens, petals and sepals - led to the formation of the ... -
Investigating the recruitment, interactions, and activity of Polycomb proteins in development and disease.
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2024)Polycomb group proteins are chromatin regulators associated with transcriptional repression of developmentally important genes. They assemble into multiprotein complexes, including Polycomb Repressive Complex 1 (PRC1) and ... -
Investigating the roles of the floral-associated genes TRIPTYCHON, SHATTERPROOF and AGAMOUS in Arabidopsis thaliana and Brassica rapa
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2024)The genetic mechanisms responsible for flower development has been studied for over four decades now in Arabidopsis thaliana, a model organism for plants. However, more recently, plant research has become increasingly ... -
RNP Granules and Neurodegeneration: Molecular Strategies to Regulate Condensation and Aggregation
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2024)Eukaryotic cell organisation is classically described in terms of a cytoplasm and discrete, membrane-bound organelles enclosed within a plasma membrane. However, more recently it has been recognised that cells also organise ... -
Secondary messenger signalling influences Pseudomonas aeruginosa adaptation to sinus and lung environments
(2024)Pseudomonas aeruginosa is a cause of chronic respiratory tract infections in people with cystic fibrosis (CF), non-CF bronchiectasis, and chronic obstructive pulmonary disease. Prolonged infection allows the accumulation ... -
The role of non-coding regulatory elements and PRC2 proteins in disease and development
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2024)Nucleosomes are the basic repeating units of chromatin. Not only do they provide a way to package the DNA into a tight nucleus, but they also contribute to the regulation of our genome. Composed of histone proteins, ... -
Understanding Tolerance to Biocides and its Consequences in Clinical Isolates of Klebsiella pneumoniae - How to Treat an ESKAPE Pathogen
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2024)Biocides such as Triclosan, Benzalkonium Chloride, and Chlorhexidine have been used as disinfectants for many years, however the effects of their use and the subsequent selective pressures applied to microbial populations ... -
The transcriptional landscape and small RNAs in Acinetobacter baumannii AB5075 during antibiotic and environmental stress.
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2024)Multi-drug resistant Acinetobacter baumannii is considered a major challenge because it causes a variety of serious infections. Studying these bacteria at the level of their genetic response could facilitate finding a way ... -
Understanding benzalkonium chloride tolerance and its implications in antibiotic resistance and other phenotypes in clinical isolates of Klebsiella pneumoniae
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2024)In this study, clinical isolates of Klebsiella pneumoniae, a Gram-negative pathogen associated with hospital acquired infections, were tested for both phenotypic and genotypic changes following adaptation to the commonly ... -
Myeloid cell-derived proteases produce a proinflammatory form of IL-37 that signals via IL-36 receptor engagement
(2022)Interleukin-1 (IL-1) family cytokines are key barrier cytokines that are typically expressed as inactive, or partially active, precursors that require proteolysis within their amino termini for activation. IL-37 is an ... -
Ancient Genomics and Human Health
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2024)Studies of ancient DNA over the last decade have been pivotal in answering archaeological, evolutionary and ecological questions. More recently, this data has also been used in the analysis of human health in the past, in ... -
Investigating the roles of SMARCA4 and EP300 in synovial sarcoma
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2024)Synovial sarcoma is a rare and aggressive cancer that accounts for approximately 10% of all soft tissue sarcomas diagnosed annually. This malignancy is caused by a characteristic fusion protein known as SS18- SSX and is ... -
Using Micro-Synteny for Phylogenetic Inference and Analysis
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2024)Phylogenetics is the study of the evolutionary relationships and history of groups of organisms. Over the past twenty years, the burgeoning number of sequenced genomes has revolutionised the field of phylogenetics taking ... -
Modulation of mitochondrial function as a therapeutic strategy for Stargardt disease and an exploration of the genetic architecture of Stargardt disease in Ireland
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2024)Inherited retinal degenerations (IRDs) are an extremely heterogeneous group of disorders, together representing the most common cause for vision loss in young people. An estimated 5.5 million people globally are living ... -
Investigating the potential to source novel postbiotics with anti-microbial or immune-modulatory activity from distillery waste
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2024)The purpose of this project is to find a novel source for antimicrobial and immunomodulatory compounds. Here we investigate the antimicrobial and immunomodulatory potential of postbiotics sourced from whisky distillation. ... -
Preventing protein-dependent biofilm formation in Staphylococcus aureus by targeting the serine aspartate repeat protein C and fibronectin binding proteins
(Trinity College (Dublin, Ireland). Department of Microbiology, 2017)Staphylococcus aureus is a leading cause of biofilm infections on indwelling medical devices. S. aureus biofilm infections are intrinsically difficult to treat. They are recalcitrant to conventional antibiotics and resistant ... -
Ecological dependencies and the illusion of cooperation in microbial communities
(2024)Ecological dependencies - where organisms rely on other organisms for survival - are a ubiquitous feature of life on earth. Multicellular hosts rely on symbionts to provide essential vitamins and amino acids. Legume plants ... -
Gene duplication in the coral genus Acropora
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2024)Whole Genome Duplications (WGD) pose major evolutionary events, giving rise to increased gene diversity. They have often been associated with major changes e.g. mass extinctions. The coral genus Acropora is a reef-building ...
