RSS 1.0Clinical Medicine (Theses and Dissertations)
Recent Submissions
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Gastrointestinal Bleeding Management and Utility of Clinical Scores in Predicting Disease and Outcome in a Modern European Population
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2025)Acute gastrointestinal bleeding remains a significant clinical challenge, with early risk stratification playing a critical role in guiding management decisions and optimizing patient outcomes. Risk scores, particularly ... -
Understanding T cell Immunity in Atopic Dermatitis: Relevance to Staphylococcus aureus Vaccine Design
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2025)In this thesis, I present original research investigating the T cell response to S. aureus in paediatric atopic dermatitis (AD). The aim of this study is to investigate the memory T cell immune response to S. aureus in ... -
Clonal haematopoiesis in telomere biology disorders influences risk of haematological malignancy and overall survival
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Telomere biology disorders (TBD) are a spectrum of diseases caused by germline variants in telomere repair and maintenance. They comprise one of the inherited bone marrow failure syndromes, a heterogenous group of disorders ... -
Inflammatory bowel disease in Ireland : epidemiology of an Irish inception cohort - results from a perspective long-term follow-up study
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2016)Ulcerative Colitis (UC) and Crohn’s Disease (CD) constitute the two main forms of Inflammatory Bowel Disease (IBD). They are chronic relapsing conditions of the gastrointestinal tract with occasional extra-gastrointestinal ... -
Post-genomic investigation of coeliac susceptibility genes
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2017)Coeliac Disease (C) is a debilitating condition characterised by chronic inflammation of the small intestine. This autoimmune disorder is triggered in genetically predispsed individuals following ingestion of dietary gluten, ... -
Polypharmacy and potentially inappropriate prescribing in community dwelling people living with Alzheimer's dementia
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Older adults are the biggest consumers of medications worldwide(1), however they are underrepresented in the clinical literature. This is true also for people living with dementia who are often excluded from clinical ... -
Dysregulated cell signalling as an oncogenic basis for the development of clear cell sarcoma of kidney (CCSK)
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2017)Clear cell sarcoma of the kidney (CCSK) is a poorly understood, aggressive, therapy resistance cancer of childhood. The lack of consistent histological or immunohistochemical features of CCSK can make this a diagnostic ... -
Cancer stem cells : the root of cisplatin resistance in non-small cell lung cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2016)Lung cancer is the leading cause of cancer-related death in Ireland and worldwide. Despite advances in anti-cancer therapies, the overall 5-year survival for non-small cell lung cancer (NSCLC) remains poor (<15%). As such, ... -
Nursing home residents in the Emergency Department (NuHR-ED): a review of resident characteristics and outcomes following Emergency Department attendance and the impact of a Nursing Home Liaison Service
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Introduction: Nursing Home (NH) residents are among the most vulnerable members of society. High rates of multimorbidity, functional dependence and frailty lead to high levels of health and social care needs in this cohort. ... -
Oesophageal adenocarcinoma cell migration and metastasis : an investigation of the scaffolding protein RACK1 as a key player and therapeutic target
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2017)The incidence of oesophageal adenocarcinoma is increasing at a rapid rate in Western countries (Pennathur et al., 2013). Early oesophageal cancer is often asymptomatic and metastatic disease is common at presentation leading ... -
Investigating the role of the transcription factor Rorα in macrophages in the context of development, inflammation and circadian rhythms
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2016)Macrophage subsets in tissue sites such as the peritoneal cavity are extremely heterogeneous in their phenotype and functions. These peritoneal macrophage subsets can be of dual origin: monocyte-derived or tissue-resident ... -
An Exploration of the feasibility of establishing a benchmark European examination in Clinical Microbiology
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, Trinity College Dublin, School of Medicine, 2024)Recruiting doctors in Clinical Microbiology (CM) in Ireland is challenging, and partly hindered by different training & scope of practice in CM across countries. Doctors training in CM in Ireland are required to sit a UK ... -
Modifiable Risk Factors for dementia, awareness of, and barriers to, brain health behaviours
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Introduction: Dementia is common and in many societies, underdiagnosed. The commonest cause of dementia globally is Alzheimer’s disease. Dementia prevalence is increasing globally. It is estimated that the number of people ... -
Investigating the Epidemiology of Mycobacterium bovis Infection in Humans in Ireland.
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Mycobacterium bovis is the main cause of bovine tuberculosis. It can cause zoonotic infection in humans. An average of 6 human M. bovis infections are notified annually in Ireland. Little is currently known about the ... -
Anal Cancer Prevention in HIV-Positive and HIV-Negative Men who have Sex with Men: (Exploring Screening tests of Another Disease State (Cervical Cancer) to Inform Future Screening Strategies for Anal Cancer and its Precursor Lesions among a High-Risk Population in Ireland.)
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Introduction: Human Papillomavirus (HPV) is the commonest sexually transmitted infection (STI) in the world. “high-risk” (hr) HPV types are associated with causing or contributing to intraepithelial neoplasia and carcinoma ... -
Small-Bowel Capsule Endoscopy Optimising Capsule Endoscopy in Clinical Practice
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)This thesis evaluated three aspects of the clinical application of small bowel cap- sule endoscopy (SBCE). The first section looked at the use of the patency capsule in clinical practice and evaluated its limitations. ... -
A PROSPECTIVE ASSESSMENT OF COLON CAPSULE ENDOSCOPY AS A COLONIC POLYP SURVEILLANCE TECHNIQUE IN IRELAND, AND FUTURE DEVELOPMENTS
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Colorectal cancer (CRC) has a significant global impact in terms morbidity and mortality. Our knowledge of its natural course, and its growth from a precursor lesion as a polyp, gives us the opportunity to prevent CRC ... -
Analysis of the Outcomes of Micro-Vascular Reconstruction following the Management Head and Neck Cancer
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Investigation of oral problems using a novel oral symptom assessment tool in patients with advanced cancer and older patients with frailty.
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, School of Medicine, 2024)Oral symptoms are common in patients with advanced cancer. Certain oral symptoms like xerostomia are common in older patients. The prevalence of many oral symptoms is however unknown in older patients with frailty. Oral ... -
Cell landscape of immunosuppressive reprogramming during fatal sepsis and severe-COVID-19 through scRNA-SEQ
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)It is evident that some patients with sepsis and septic shock are admitted to hospitals late in their illness, contributing to poor outcomes and high mortality rates across all age groups worldwide. Current diagnostic and ...
