RSS 1.0Dental Science (Scholarly Publications)
Recent Submissions
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Deletion of the Candida albicans TLO gene family results in alterations in membrane sterol composition and fluconazole tolerance.
(2024)Development of resistance and tolerance to antifungal drugs in Candida albicans can compromise treatment of infections caused by this pathogenic yeast species. The uniquely expanded C. albicans TLO gene family is comprised ... -
Variations in candidalysin amino acid sequence influence toxicity and host responses.
(2024)Candida albicans causes millions of mucosal infections in humans annually. Hyphal overgrowth on mucosal surfaces is frequently associated with tissue damage caused by candidalysin, a secreted peptide toxin that destabilizes ... -
PROTRACTED TRANSMISSION AND PERSISTENCE OF ST80 VANCOMYCIN-RESISTANT Enterococcus faecium CLONAL COMPLEX TYPES CT2933, CT2932 AND CT1916 IN A LARGE IRISH HOSPITAL: A 39-MONTH WGS STUDY
(2024)Background: Vancomycin-resistant Enterococcus faecium (VREfm) are significant nosocomial pathogens. Sequence type (ST)80 vanA-encoding VREfm predominate in Irish hospitals, but their transmission is poorly understood. Aims: ... -
Deletion of the Candida albicans TLO gene family using CRISPR-Cas9 mutagenesis allows characterisation of functional differences in ¿-, ß- and ¿- TLO gene function.
(2023)The Candida albicans genome contains between ten and fifteen distinct TLO genes that all encode a Med2 subunit of Mediator. In order to investigate the biological role of Med2/Tlo in C. albicans we deleted all fourteen TLO ... -
Does fluoride exposure impact on the human microbiome?
(2023)Fluoride is added to drinking water in some countries to prevent tooth decay (caries). There is no conclusive evidence that community water fluoridation (CWF) at WHO recommended concentrations for caries prevention has any ... -
A dentifrice containing salivary enzymes and xylitol exhibits superior antimicrobial activity in vitro against adherent Streptococcus mutans compared to a chlorhexidine dentifrice.
(2023)Human saliva contains natural antimicrobial enzymes. In this in-vitro study, we evaluate the antimicrobial activity of a dentifrice containing a salivary enzyme complex (SEC) with xylitol versus a standard 0.12% chlorhexidine ... -
Alcohol consumption modulates Candida albicans-induced oral carcinogenesis and progression
(2023)Objectives: This study aimed to determine the impact of low levels of alcohol consumption on the interaction of the oral cavity with Candida albicans, a species that is commonly found at higher levels in the oral cavities ... -
Impact of pulpectomy versus tooth extraction in children's oral health-related quality of life: A randomized clinical trial
(2023)Aim: The aim of this randomized clinical trial was to compare the impact of two management options for primary molars with pulp necrosis (pulpectomy or extraction) on children's oral health-related quality of life ... -
Stainless steel crown vs bulk fill composites for the restoration of primary molars post-pulpectomy: 1-year survival and acceptance results of a randomized clinical trial
(2022)Background: A key factor for the success and longevity of the endodontic treatment is sealing of the cavity after restorative treatment. Aim: The aim of this randomised clinical trial was to evaluate the 1-year survival ... -
General dentists' perceptions and clinical management of hypomineralised second primary molars (HSPM) in Ireland
(2023)Purpose: This questionnaire aimed to explore how general dentists in the Republic of Ireland perceive and manage hypomineralised second primary molars (HSPM). Methods: Following ethical approval, a validated structured ... -
Pulp Vitality and Longevity of Adhesive Restorations Are Not Affected by Selective Carious Removal: A Multicenter Clinical Trial
(2021)The aim of this multicenter randomized clinical trial was to evaluate the pulp vitality and survival rate of adhesive restorations performed on posterior deciduous teeth after non-selective (NSCR) or selective (SCR) carious ... -
Clinical experience of undergraduate dental students in paediatric dentistry: A 5-year cross-sectional study
(2022)Introduction: The clinical experience of undergraduate dental students in Paediatric Dentistry has a profound influence on their future confidence. The purpose of this study was to evaluate the clinical experience of ... -
Giomer composite compared to glass ionomer in occlusoproximal ART restorations of primary molars: 24-month RCT
(2022)Background Occlusoproximal restorations of primary molars usually fail, so it is necessary to investigate new materials that may overcome this challenge. Thus, this trial aimed to evaluate the longevity of occlusoproximal ... -
The Hall Technique 10 years on: Questions and answers.
(2017)It is ten years since the first paper on the Hall Technique was published in the British Dental Journal and almost 20 years since the technique first came to notice. Dr Norna Hall a (now retired) general dental practitioner ... -
Glass Ionomer Sealants Can Prevent Dental Caries but Cannot Prevent Posteruptive Breakdown on Molars Affected by Molar Incisor Hypomineralization: One-Year Results of a Randomized Clinical Trial
(2021)To evaluate the preventive effect of glass ionomer cement (GIC) against dental caries and posteruptive breakdown (PEB) on molars affected by molar incisor hypomineralization (MIH). In this randomized clinical trial, 77 ... -
Survival rate of primary molar restorations is not influenced by hand mixed or encapsulated GIC: 24 months RCT
(2021)Background: Glass ionomer cements (GIC) have been considered the top option to restore primary teeth by dentists. The most common supply forms are hand mixed and encapsulated GIC. There is a lack of information about the ... -
Is it worth using low-cost glass ionomer cements for occlusal ART restorations in primary molars? 2-year survival and cost analysis of a Randomized clinical trial
(2020)Objective: To evaluate the 2-year survival rate and the cost-effectiveness of Atraumatic Restorative Treatment (ART) using three different glass ionomer cements (GICs) for restoring occlusal dentin caries lesions in primary ... -
Use of rubber dam versus cotton roll isolation on composite resin restorations' survival in primary molars: 2-year results from a non-inferiority clinical trial.
(2022)Background: This non-inferiority randomised clinical trial aimed to evaluate the survival of direct bulk fill composite resin restorations in primary molars using different methods of moisture control: rubber dam isolation ... -
IMMERSION OF DEBRIDED DIABETIC FOOT ULCER (DFU) TISSUE IN ELECTROCHEMICALLY GENERATED PH NEUTRAL HYPOCHLOROUS ACID SIGNIFICANTLY REDUCES THE MICROBIAL BIOBURDEN: WHOLE-GENOME SEQUENCING OF Staphylococcus aureus, THE MOST PREVALENT SPECIES RECOVERED
(2023)Background: Diabetic foot ulcer infections (DFUIs) are the leading cause of lower limb amputations, mediated predominantly by Staphylococcus aureus. pH neutral electrochemically-generated hypochlorous acid (anolyte) is a ... -
The role of the Mediator complex in fungal pathogenesis and response to antifungal agents.
(2023)Mediator is a complex of polypeptides that plays a central role in the recruitment of RNA polymerase II to promoters and subsequent transcriptional activation in eukaryotic organisms. Studies have now shown that Mediator ...
