Microbiology (Scholarly Publications)
Recent Submissions
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Aspergillus fumigatus mitogen-activated protein kinase MpkA is involved in gliotoxin production and self-protection
(2024)Aspergillus fumigatus is a saprophytic fungus that can cause a variety of human diseases known as aspergillosis. Mycotoxin gliotoxin (GT) production is important for its virulence and must be tightly regulated to avoid ... -
Secondary messenger signalling influences Pseudomonas aeruginosa adaptation to sinus and lung environments
(2024)Pseudomonas aeruginosa is a cause of chronic respiratory tract infections in people with cystic fibrosis (CF), non-CF bronchiectasis, and chronic obstructive pulmonary disease. Prolonged infection allows the accumulation ... -
Ecological dependencies and the illusion of cooperation in microbial communities
(2024)Ecological dependencies - where organisms rely on other organisms for survival - are a ubiquitous feature of life on earth. Multicellular hosts rely on symbionts to provide essential vitamins and amino acids. Legume plants ... -
Community composition drives siderophore dynamics in multispecies bacterial communities.
(2023)Background Intraspecific public goods are commonly shared within microbial populations, where the benefits of public goods are largely limited to closely related conspecifics. One example is the production of iron-scave ... -
Ecological selection of siderophore-producing microbial taxa in response to heavy metal contamination
(2018)Some microbial public goods can provide both individual and community-wide benefits, and are open to exploitation by non-producing species. One such example is the production of metaldetoxifying siderophores. Here, we ... -
No effect of intraspecific relatedness on public goods cooperation in a complex community
(2018)Many organisms—notably microbes—are embedded within complex communities where cooperative behaviors in the form of excreted public goods can benefit other species. Under such circumstances, intraspecific interactions are ... -
Transposable temperate phages promote the evolution of divergent social strategies in Pseudomonas aeruginosa populations
(2019)Transposable temperate phages randomly insert into bacterial genomes, providing increased supply and altered spectra of mutations available to selection, thus opening alternative evolutionary trajectories. Transposable ... -
Cultivating antimicrobial resistance: how intensive agriculture ploughs the way for antibiotic resistance
(2023)Antimicrobial resistance (AMR) is a growing threat to public health, global food security and animal welfare. Despite efforts in antibiotic stewardship, AMR continues to rise worldwide. Anthropogenic activities, particularly ... -
Resource heterogeneity and the evolution of public goods cooperation
(2020)Heterogeneity in resources is a ubiquitous feature of natural landscapes affecting many aspects of biology. However, the effect of environmental heterogeneity on the evolution of cooperation has been less well studied. ... -
Species interactions drive the spread of ampicillin resistance in human-associated gut microbiota
(2021)Background and objectives: Slowing the spread of antimicrobial resistance is urgent if we are to continue treating infectious diseases successfully. There is increasing evidence microbial interactions between and within ... -
Stress causes interspecific facilitation within a compost community
(2021)Ecological theory predicts interactions between species to become more positive under abiotic stress, while competition should prevail in more benign environments. However, experimental tests of this stress gradient ... -
Development of liquid culture media mimicking the conditions of sinuses and lungs in cystic fibrosis and health
(2022)The respiratory tract is a compartmentalised and heterogenous environment. The nasopharynx and sinuses of the upper airways have distinct properties from the lungs and these differences may shape bacterial adaptation ... -
Aneuploidy influences the gene expression profiles in Saccharomyces pastorianus group I and II strains during fermentation
(2022)The lager yeasts, Saccharomyces pastorianus, are hybrids of Saccharomyces cerevisiae and Saccharomyces eubayanus and are divided into two broad groups, Group I and II. The two groups evolved from at least one common ... -
Packing a punch: Understanding how flavours are produced in lager fermentations
(2021)Beer is one of the most popular beverages in the world and it has an irreplaceable place in culture. Although invented later than ale, lager beers dominate the current market. Many factors relating to the appearance (colour, ... -
Population genomics of the pathogenic yeast Candida tropicalis identifies hybrid isolates in environmental samples
(2021)Candida tropicalis is a human pathogen that primarily infects the immunocompromised. Whereas the genome of one isolate, C. tropicalis MYA-3404, was originally sequenced in 2009, there have been no large-scale, multi-isolate ... -
Transcriptional Profile of the Industrial Hybrid Saccharomyces pastorianus Reveals Temperature-Dependent Allele Expression Bias and Preferential Orthologous Protein Assemblies
(2021)Saccharomyces pastorianus is a natural yeast evolved from different hybridization events between the mesophilic S. cerevisiae and the cold-tolerant S. eubayanus. This complex aneuploid hybrid carries multiple copies of the ... -
A Novel Method to Identify and Characterise Peptide Mimotopes of Heat Shock Protein 70-associated antigens
(2006)The heat shock protein, Hsp70, has been shown to play an important role in tumour immunity. Vaccination with Hsp70-peptide complexes (Hsp70-PCs), isolated from autologous tumour cells, can induce protective immune responses. ... -
The complex and dynamic genomes of industrial yeasts
(2009)The Saccharomyces sensu stricto genus contains many species that are industrially important for fermentation of wines, beers and ales. The molecular characterization of the genomes of yeasts involved in these processes ... -
Recombination Sites on Hybrid Chromosomes in S. pastorianus share Common Sequence Motifs and define a Complex Evolutionary Relationship between Group I and II Lager Yeasts
(2017)Saccharomyces pastorianus, referred to as lager yeasts, are hybrids of S. cerevisiae and S. eubayanus. Isolates within the species are divided into two groups (I and II) based on chromosome structure and composition. ... -
Fermentation innovation through complex hybridization of wild and domesticated yeasts
(2019)The most common fermented beverage, lager beer, is produced by interspecies hybrids of the brewing yeast Saccharomyces cerevisiae and its wild relative S. eubayanus. Lager-brewing yeasts are not the only example of hybrid ...