Browsing Pharmacology & Therapeutics (Scholarly Publications) by Title
Now showing items 1-20 of 39
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Alzheimer's disease A� assemblies mediating rapid disruption of synaptic plasticity and memory.
(2012)Alzheimer’s disease (AD) is characterized by episodic memory impairment that often precedes clinical diagnosis by many years. Probing the mechanisms of such impairment may provide much needed means of diagnosis and therapeutic ... -
Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory.
(2008)Alzheimer?s disease (AD) constitutes a rising threat to public health. Despite extensive research in cellular and animal models, identifying the pathogenic agent present in the human brain and showing that it confers key ... -
Antimicrobial management and appropriateness of treatment of urinary tract infection in general practice in Ireland.
(2011)BACKGROUND: Urinary tract infections (UTIs) are the second most common bacterial infections in general practice and a frequent indication for prescription of antimicrobials. Increasing concern about the association between ... -
Aß Facilitates LTD at Schaffer Collateral Synapses Preferentially in the Left Hippocampus
(2018)Promotion of long-term depression (LTD) mechanisms by synaptotoxic soluble oligomers of amyloid-β (Aß) has been proposed to underlie synaptic dysfunction in Alzheimer’s disease (AD). Previously, LTD was induced by relatively ... -
A cohort study of metformin exposure and survival in patients with stage I-III colorectal cancer
(2013)Background: Preclinical evidence suggests a beneficial effect of metformin in colorectal cancer. This study aimed to investigate associations between metformin exposure and colorectal cancer–specific survival using ... -
Comparing primary prevention with secondary prevention to explain decreasing coronary heart disease death rates in Ireland 1985 - 2000
(2007)BACKGROUND: To investigate whether primary prevention might be more favourable than secondary prevention (risk factor reduction in patients with coronary heart disease(CHD)). METHODS: The cell-based IMPACT CHD mortality ... -
A competing risks prescription refill model of compliance and persistence.
(2010)Objectives There is evidence to suggest that noncompliant and nonpersistent behaviors have differing risk factors, clinical consequences, and responses to intervention. This has led to calls for these behaviors to be defined ... -
Cyclooxygenase-2 inhibition improves amyloid-beta-mediated suppression of memory and synaptic plasticity
(Oxford University Press, 2008)Non-steroidal anti-inflammatory agents (NSAIDs) are associated with a marked reduction in the risk of developing Alzheimer's disease, a form of dementia characterized by the accumulation of amyloid plaques containing the ... -
DIFFERENTIAL INTERACTIONS OF ANTIRETROVIRAL AGENTS WITH LXR, ER AND GR NUCLEAR RECEPTORS - POTENTIAL CONTRIBUTING FACTORS OF ADVERSE EVENTS
(2014)BACKGROUND AND PURPOSE: Antiretroviral (ARV) drugs activate pregnane X receptors and constitutive androstane receptors, increasing the risk of drug interactions due to altered drug metabolism and disposition. The closely ... -
Elimination half-life may explain the relative efficacy of boceprevir and telaprevir in the treatment of hepatitis c virus genotype 1
(2013)Background. The licensing of direct-acting antivirals heralds a new era in the treatment of hepatitis C virus (HCV) genotype 1. We undertook a mixed treatment comparison to examine the relative efficacy among current ... -
Exosomes neutralize synaptic-plasticity-disrupting activity of Aß assemblies in vivo.
(2013)Abstract BACKGROUND: Exosomes, small extracellular vesicles of endosomal origin, have been suggested to be involved in both the metabolism and aggregation of Alzheimer's disease (AD)-associated amyloid β-protein (Aβ). ... -
Extracellular forms of A� and tau from iPSC models of Alzheimer's disease disrupt synaptic plasticity
(2018)The early stages of Alzheimer’s disease are associated with synaptic dysfunction prior to overt loss of neurons. To identify extracellular molecules that impair synaptic plasticity in the brain, we studied the secretomes ... -
Fasting plasma glucose as initial screening for diabetes and prediabetes in irish adults: The diabetes mellitus and vascular health initiative (DMVhi)
(2015)OBJECTIVE: Type 2 diabetes has a long pre clinical asymptomatic phase. Early detection may delay or arrest disease progression. The Diabetes Mellitus and Vascular health initiative (DMVhi) was initiated as a prospective ... -
GluN2B subunit-containing NMDA receptor antagonists prevent Abeta-mediated synaptic plasticity disruption in vivo
(2009)Currently, treatment with the relatively low-affinity NMDA receptor antagonist memantine provides limited benefit in Alzheimer's disease (AD). One probable dose-limiting factor in the use of memantine is the inhibition of ... -
Glutamate receptors in preclinical research on Alzheimer's disease: update on recent advances
(2012)The cognitive and related symptoms of Alzheimer's disease are mainly attributable to synaptic failure. Here we review recent research on how the Alzheimer's disease amyloid ?-protein (A?) affects glutamate receptors and ... -
Hepatitis C in the era of direct-acting antivirals: real-world costs of untreated chronic hepatitis C; a cross-sectional study.
(2015)ACKGROUND: Recent advances in Hepatitis C therapeutics offer the possibility of cure but will be expensive. The cost of treatment may be partially offset by the avoidance of advanced liver disease. We performed a ... -
Interaction between prion protein and toxic amyloid ß assemblies can be therapeutically targeted at multiple sites.
(2011)A role for PrP in the toxic effect of oligomeric forms of A?, implicated in Alzheimer's disease (AD), has been suggested but remains controversial. Here we show that PrP is required for the plasticity-impairing effects of ... -
Medicinal plants used by traditional medicine practitioners for the treatment of HIV/AIDS and related conditions in Uganda
(Elsevier, 2010)Introduction and objectives: In Uganda, there are over 1 million people with HIV/AIDS. When advanced, this disease is characterized by life-threatening opportunistic infections. As the formal health sector struggles to ...
