Browsing by Subject "macrophages"
Now showing items 1-5 of 5
-
Bridging the gap – a new role for STAT3 in TLR4-mediated metabolic reprogramming
(2021)In this article, we discuss a new study from the laboratory of Ashley Mansell that successfully links innate immune receptor signaling to metabolic changes in macrophages, establishing for the first time an uninterrupted ... -
Notch-RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization.
(2012)Emerging concepts suggest that the functional phenotype of macrophages is regulated by transcription factors that define alternative activation states. We found that RBP-J, the main nuclear transducer of signaling via Notch ... -
Role of the Elongator complex in innate immune responses of macrophages
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)The innate immune system functions as the first line of defence against pathogen infection. Innate immune systems are functionally present across the animal kingdom and mediate host defence against infection via a myriad ... -
Signaling metabolite L-2-hydroxyglutarate activates the transcription factor HIF-1α in lipopolysaccharide-activated macrophages
(2022)Activated macrophages undergo metabolic reprogramming, which not only supports their energetic demands but also allows for the production of specific metabolites that function as signaling molecules. Several Krebs cycles, ... -
Th1-Th2 polarisation and autophagy in the control of intracellular mycobacteria by macrophages
(Elsevier, 2009)Autophagy is a recently recognized immune effector mechanism against intracellular pathogens. The role of autophagy in innate immunity has been well established, but the extent of its regulation by the adaptive immune ...
