Browsing by Subject "innate immunity"
Now showing items 1-9 of 9
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Delineating the mechanisms utilised by Staphylococcus aureus to survive intracellularly within phagocytes
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)Staphylococcus aureus (S. aureus) is a major human pathogen in addition to being an important part of the human microbiome. The bacterium has evolved a large array of immune evasion mechanisms to facilitate its persistence ... -
From periphery to center stage: 50 years of advancements in innate immunity
(2024)Over the past 50 years in the field of immunology, something of a Copernican revolution has happened. For a long time, immunologists were mainly concerned with what is termed adaptive immunity, which involves the exquisitely ... -
Inflammasome activation: from inflammatory disease to infection
(2011)The recognition of pathogen-derived molecules by the innate immune system is mediated by a number of receptors, including members of the TLR (Toll-like receptor), RLH [RIG (retinoic acid-inducible gene)-like helicase] and ... -
Mechanisms of gasdermin pore formation in response to viral sensing in human respiratory epithelial cells
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)A key component of the innate immune response to infection or cellular stress is the activation of inflammasomes which leads to gasdermin (GSDM) pore formation, interleukin-1β (IL-1β) release and lytic cell death. GSDMs ... -
Microrna regulation of bovine monocyte inflammatory and metabolic networks in an in Vivo infection model
(2014)Bovine mastitis is an inflammation-driven disease of the bovine mammary gland that costs the global dairy industry several billion dollars per year. Because disease susceptibility is a multifactorial complex phenotype, an ... -
PAEDIATRIC OUTCOMES AND SERUM BIOMARKER PANEL IN ACUTE TRAUMATIC BRAIN INJURY /CONCUSSION TO SEVERE TRAUMATIC BRAIN INJURY
(Trinity College Dublin. School of Medicine. Discipline of Paediatrics, 2020)Introduction Paediatric mild traumatic brain injury (mTBI) is increasingly recognised to have significant longer term neurocognitive effects. Childhood is a time of high risk for head injury. There were no national ... -
Regulation of bovine beta-defensin expression
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2017)Beta-defensins are a class of host defence peptides with antibacterial, antiviral and immunomodulatory roles. The bovine genome contains up to 57 putative beta-defensin genes in four syntenic clusters on different chromosomes. ... -
The TLR signaling adaptor TRAM interacts with TRAF6 to mediate activation of the inflammatory response by TLR4.
(2014)TLRs act as sentinels in professional immune cells to detect and initiate the innate immune response to pathogen challenge. TLR4 is a widely expressed TLR, responsible for initiating potent immune responses to LPS. TRAM ... -
Unlocking potential: the role of the electron transport chain in immunometabolism
(2024)The electron transport chain (ETC) couples electron transfer with proton pumping to generate ATP and it also regulates particular innate and adaptive immune cell function. While NLRP3 inflammasome activation was initially ...
